Summary: Researchers provide further evidence that physical activity can help to protect people from developing depressive symptoms.
Source: King’s College London.
An international team including researchers from King’s College London have found physical activity can protect against the emergence of depression, regardless of age and geographical region.
The researchers from Brazil, Belgium, Australia, USA, UK and Sweden pooled data from 49 unique cohort studies of people free from mental illness that examined if physical activity is associated with a decreased risk of developing depression.
In total, 266,939 individuals were included, with a gender distribution of 47% males, and on average the individuals were followed up after 7.4 years.
Once the data were extracted they found that compared with people with low levels of physical activity, those with high levels had lower odds of developing depression in the future.
Furthermore, physical activity had a protective effect against the emergence of depression in youths, in adults, and in the elderly and across geographical regions, (in Europe, North America, and Oceania).
Lead author Professor Dr Felipe Barreto Schuch, Universidade La Salle (Brazil), said, ‘This is the first global meta-analysis to establish that engaging in physical activity is beneficial for protecting the general population from developing depression.’
‘The evidence is clear that people that are more active have a lesser risk of developing depression. We have looked at whether these effects happen at different age groups and across different continents and the results are clear. Regardless your age or where you live, physical activity can reduce the risk of having depression later in life.’
Co-author Dr Brendon Stubbs, Post-doctoral research physiotherapist, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and Head of Physiotherapy, South London and Maudsley NHS Foundation Trust, said,
‘Our robust analysis of over a quarter of a million people found consistent evidence that people who are more active are less likely to develop depression in the future.
We found that higher levels of physical activity were protective from future depression in children, adults and older adults, across every continent and after taking into account other important factors such as body mass index, smoking and physical health conditions.
‘Given the multitude of other health benefits of physical activity, our data add to the pressing calls to prioritise physical activity across the lifespan.’
Co-author Dr Simon Rosenbaum, Senior Research Fellow at UNSW Sydney and the Black Dog Institute, said, ‘The challenge ahead is ensuring that this overwhelming evidence is translated into meaningful policy change that creates environments and opportunities to help everyone, including vulnerable members of our society, engage in physical activity’.
Co-author Dr Joseph Firth, Research Fellow at NICM Health Research Institute at Western Sydney University said, ‘The compelling evidence presented here provides an even stronger case for engaging all people in regular physical activity; through schools, workplaces, leisure programs and elsewhere, in order to reduce the risk of depression across the lifespan.’
Further studies are warranted to evaluate the minimum physical activity levels required and the effects of different types of activity and ‘dosages’ on subsequent risk for depression.
Funding: Dr Brendon Stubbs is supported in part by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South London, where he is part of a team investigating ways to help people with severe mental illness to improve their physical health. Dr Stubbs is also partially funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.
Source: Alex Booth – King’s College London
Publisher: Organized by NeuroscienceNews.com.
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Original Research: Abstract for “Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies” by Felipe B. Schuch, Ph.D., Davy Vancampfort, Ph.D., Joseph Firth, Ph.D., Simon Rosenbaum, Ph.D., Phillip B. Ward, Ph.D., Edson S. Silva, B.Sc., Mats Hallgren, Ph.D., Antonio Ponce De Leon, Ph.D., Andrea L. Dunn, Ph.D., Andrea C. Deslandes, Ph.D., Marcelo P. Fleck, Ph.D., Andre F. Carvalho, Ph.D., Brendon Stubbs, Ph.D. in American Journal of Psychiatry. Published April 23 2018.
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies
The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators.
Prospective cohort studies evaluating incident depression were searched from database inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. Demographic and clinical data, data on physical activity and depression assessments, and odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted. Random-effects meta-analyses were conducted, and the potential sources of heterogeneity were explored. Methodological quality was assessed using the Newcastle-Ottawa Scale.
A total of 49 unique prospective studies (N=266,939; median proportion of males across studies, 47%) were followed up for 1,837,794 person-years. Compared with people with low levels of physical activity, those with high levels had lower odds of developing depression (adjusted odds ratio=0.83, 95% CI=0.79, 0.88; I2=0.00). Furthermore, physical activity had a protective effect against the emergence of depression in youths (adjusted odds ratio=0.90, 95% CI=0.83, 0.98), in adults (adjusted odds ratio=0.78, 95% CI=0.70, 0.87), and in elderly persons (adjusted odds ratio=0.79, 95% CI=0.72, 0.86). Protective effects against depression were found across geographical regions, with adjusted odds ratios ranging from 0.65 to 0.84 in Asia, Europe, North America, and Oceania, and against increased incidence of positive screen for depressive symptoms (adjusted odds ratio=0.84, 95% CI=0.79, 0.89) or major depression diagnosis (adjusted odds ratio=0.86, 95% CI=0.75, 0.98). No moderators were identified. Results were consistent for unadjusted odds ratios and for adjusted and unadjusted relative risks/hazard ratios. Overall study quality was moderate to high (Newcastle-Ottawa Scale score, 6.3). Although significant publication bias was found, adjusting for this did not change the magnitude of the associations.
Available evidence supports the notion that physical activity can confer protection against the emergence of depression regardless of age and geographical region.