‘Stealth Transmission’ Fuels Fast Spread of COVID-19 Outbreak

Summary: Undetected and undocumented cases of COVID-19 were largely responsible for the rapid spread of the virus in China. 86% of all infections were undocumented before the January 23 Wuhan travel shutdown. Per person, the undocumented infections were half as contagious as documented infections but were the source of two-thirds of documented infections.

Source: Columbia University Mailman School of Public Health

Undetected cases, many of which were likely not severely symptomatic, were largely responsible for the rapid spread of the COVID-19 outbreak in China, according to new research by scientists at Columbia University Mailman School of Public Health. The findings based on a computer model of the outbreak are published online in the journal Science.

The researchers report:

• 86 percent of all infections were undocumented prior to the January 23 Wuhan travel shutdown
• Per person, these undocumented infections were half (52 percent) as contagious as documented infections yet were the source of two-thirds of documented infections
• Government control efforts and population awareness have reduced the rate of spread of the virus in China; after travel restrictions and control measures were imposed, it spread less quickly

“The explosion of COVID-19 cases in China was largely driven by individuals with mild, limited, or no symptoms who went undetected,” says co-author Jeffrey Shaman, PhD, professor of environmental health sciences at Columbia University Mailman School. “Depending on their contagiousness and numbers, undetected cases can expose a far greater portion of the population to virus than would otherwise occur. We find for COVID-19 in China these undetected infected individuals are numerous and contagious. These stealth transmissions will continue to present a major challenge to the containment of this outbreak going forward.”

The researchers used a computer model that draws on observations of reported infection and spread within China in conjunction with mobility data from January 10-23 and January 24-February 8. They caution that major changes to care-seeking or patient documentation practices, as well as rapid developments with regard to travel restrictions and control measures, may make predictions difficult.

This shows a woman in a face mask
86 percent of all infections were undocumented prior to the January 23 Wuhan travel shutdown. The image is in the public domain.

“Heightened awareness of the outbreak, increased use of personal protective measures, and travel restriction have helped reduce the overall force of infection; however, it is unclear whether this reduction will be sufficient to fully stem the virus spread,” says Shaman. “If the novel coronavirus follows the pattern of 2009 H1N1 pandemic influenza, it will also spread globally and become a fifth endemic coronavirus within the human population.”

Additional co-authors include first author Ruiyun Li, Imperial College London, London; Bin Chen, University of California, Davis; Yimeng Song, University of Hong Kong; Tao Zhang, Tsinghua University, Beijing; and Sen Pei and Wan Yang at the Columbia Mailman School.

A version of the article was posted in February in medRxiv, a preprint server for health sciences.

Funding: This research was supported by U.S. National Institutes of Health grants (GM110748, AI145883). Shaman and Columbia University report partial ownership of SK Analytics, a provider of influenza forecasting and analytics services. Shaman also reports receiving consulting fees from Merck.

[divider]About this SARS-CoV-2 research article[/divider]

Source:
Columbia University Mailman School of Public Health
Media Contacts:
Press Office – Columbia University Mailman School of Public Health
Image Source:
The image is in the public domain.

Original Research: Open access
“Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)”. Ruiyun Li, Sen Pei, Bin Chen, Yimeng Song, Tao Zhang, Wan Yang, Jeffrey Shaman.
Science doi:10.1126/science.abb3221.

Abstract

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2)

Estimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease. Here we use observations of reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model and Bayesian inference, to infer critical epidemiological characteristics associated with SARS-CoV2, including the fraction of undocumented infections and their contagiousness. We estimate 86% of all infections were undocumented (95% CI: [82%–90%]) prior to 23 January 2020 travel restrictions. Per person, the transmission rate of undocumented infections was 55% of documented infections ([46%–62%]), yet, due to their greater numbers, undocumented infections were the infection source for 79% of documented cases. These findings explain the rapid geographic spread of SARS-CoV2 and indicate containment of this virus will be particularly challenging.

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