Eyes hold clues for treating severe autism more effectively

Summary: Tracking eye movement and pupil dilation in those with level 3 Autism helped assess true language abilities.

Source: University of Vermont

Vocabulary tests for individuals with the severest forms of autism spectrum disorder, or ASD, are notoriously inaccurate. They commonly ask the test-taker to point to an illustration after hearing a spoken word, measuring the ability to understand and perform a task as much as word knowledge.

The implications are significant. Poor assessments result not only in teaching strategies that are ineffective but also make researchers wary, leading to a shortage of research on individuals with Level 3 ASD, the diagnosis given to the most severe forms of autism, that could help improve their quality of life.

That’s according to Emily Coderre, lead author of a new study in the journal Cognitive and Behavioral Neurology and a faculty member in the University of Vermont’s Department of Communication Science and Disorders.

In the new study, Coderre and colleagues at Johns Hopkins Medicine demonstrate that assessment tools capturing implicit signs of word knowledge like eye movement among those with Level 3 ASD – tools that have rarely been used with this group – offer the potential to be more accurate than traditional behavioral assessments, closely matching the reports of parents and caregivers, the current “gold standard” for determining an individual’s vocabulary knowledge.

“Children and adults with severe ASD often score much lower than they should on traditional language assessments,” Coderre said. “They may not understand the instructions or be unable to point to a picture after hearing the spoken word. Or they may be frightened by the equipment or simply not care to participate. The new study points the way toward a much better approach.”

Three implicit measures of word knowledge

To assess vocabulary knowledge among five adults with Level 3 ASD, researchers in the study used what are called implicit measures of word knowledge.

In one test researchers used a technique called eye movement monitoring. After hearing a spoken word, which matched one of four illustrations on a computer screen, the researchers tracked the subjects’ eye movements. If their eyes quickly chose the matching visual and stayed with it, that signaled knowledge of the word. If the eyes flitted from one object to the next, it demonstrated the word was probably not known.

In a second test called pupillary dilation, subjects again heard a spoken word and were shown four visuals. If the pupils dilated, that signaled cognitive effort and the probability that the word was not known. If pupils did not dilate, that likely demonstrated knowledge of the word.

In a third test, researchers used electroencephalography to measure brain activity in the research subjects. Subjects heard a word and were shown an image that either matched or did not match it. Earlier research has shown there are typical brain patterns for congruent and incongruent pairs of words and images, enabling the researchers to infer whether the word was known based on these electrical signatures.

The three measures had varying degrees of accuracy with each of the five research subjects. Although the researchers concluded that these implicit measures show promise in providing estimates of vocabulary knowledge, this variability suggests that these assessments should be tailored to each individual.

An earlier study by the research team offered further validation of the research findings. That study found that the three implicit measures were highly accurate in assessing word knowledge among a group of adults who did not have ASD.

Better interventions, more knowledge

Given the small research sample, the research findings are preliminary. But their potential implications are significant, Coderre said.

Implicit measures of vocabulary could result in more effective interventions that are tailored to the true language knowledge of the individual.

“Language is often one of the areas where individuals with autism struggle, especially at the more severe end of the spectrum, where a large percentage have little to no functional language,” Coderre said. “Anything we can do to improve their language outcomes will improve their quality of life.”

This shows images of objects used in the eye tracking assessment

In one of the implicit measures in the study, participants with severe autism heard a word and were asked to match it to one of four images. If their eyes quickly went to one of the images (as in the screen to the right), that signaled it was a known word. It the word was unknown, the eyes flitted from one image to the next (as in the screen to the left). This implicit measure and two others researchers tested demonstrated the potential to be more accurate than conventional word assessment approaches for those with severe autism. The image is adapted from the University of Vermont news release.

The new tools could also result in more research into those with severe ASD, she said, not only in language acquisition but in other areas of cognition.

Nonverbal intelligence testing often relies on visual clues, for instance, she said. Subjects might be shown an image of a puzzle with a missing piece and be asked to find the piece among several options, a task well suited to the EM and PD testing.

“These techniques could very well be extended to other domains,” Coderre said.

That could help address a challenge in the field – the huge lack of literature on individuals with Level 3 ASD.

“There’s so much focus on the milder end of the spectrum, the people who are more functionally verbal, that people on the more severe end of the spectrum tend to be overlooked,” Coderre said.

“With measures like these, we can do not only more interventions-based research, but also work with this population in general, so we can better understand how their strengths and weaknesses are similar to or different from other individuals on the spectrum. The more understanding we have, the more help we can offer.”

About this neuroscience research article

Source:
University of Vermont
Media Contacts:
Jeff Wakefield – University of Vermont
Image Source:
The image is adapted from the University of Vermont news release.

Original Research: Open access
“Implicit Measures of Receptive Vocabulary Knowledge in Individuals With Level 3 Autism”. Emily Coderre; Mariya Chernenok; Jessica O’Grady; Laura Bosley; Barry Gordon; Kerry Ledoux;.
Cognitive and Behavioral Neurology. doi:10.1097/WNN.0000000000000194

Abstract

Implicit Measures of Receptive Vocabulary Knowledge in Individuals With Level 3 Autism

Implicit measures of cognition are essential for assessing knowledge in people with Level 3 autism because such individuals are often unable to make reliable overt behavioral responses. In this study, we investigated whether three implicit measures—eye movement (EM) monitoring, pupillary dilation (PD), and event-related potentials (ERPs)—can be used to reliably estimate vocabulary knowledge in individuals with Level 3 autism. Five adults with Level 3 autism were tested in a repeated-measures design with two tasks. High-frequency ‘known’ words (eg, bus, airplane) and low-frequency ‘unknown’ words (eg, ackee, cherimoya) were presented in a visual world task (during which EM and PD data were collected) and a picture-word congruity task (during which ERP data were collected). Using a case-study approach with single-subject analyses, we found that these implicit measures have the potential to provide estimates of receptive vocabulary knowledge in individuals with Level 3 autism. Participants differed with respect to which measures were the most sensitive and which variables best predicted vocabulary knowledge. These implicit measures may be useful to assess language abilities in individuals with Level 3 autism, but their use should be tailored to each individual.

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