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Brain Circuit That Supports Smoking Cessation Identified

Summary: Researchers report a person’s ability to quit smoking could be influenced by a neural network associated with inhibiting automated behavior.

Source: Medical University of South Carolina.

The ability to quit smoking is influenced by a brain circuit that is responsible for inhibiting automated behavior, report researchers at the Medical University of South Carolina Hollings Cancer Center in the March 1, 2017 issue of JAMA Psychiatry.

Quitting smoking is hard. Yet success is more likely with strong communication between parts of the brain that inhibit and execute automated behavior, report researchers at the Medical University of South Carolina (MUSC) in the March 1, 2017 issue of JAMA Psychiatry.

Smoking becomes an automated behavior over time, according to Brett Froeliger, Ph.D., an addiction scientist in the MUSC Department of Neuroscience and Hollings Cancer Center and first author on the study.

In the brain, the urge to smoke begins the same way your foot automatically moves to the gas pedal when a red stoplight turns green. “A pack-a-day smoker places a cigarette in their mouth a few hundred times a day over years,” said Froeliger. “It becomes automated.”

One way the brain inhibits automated behavior is through a pathway called the inhibitory control network, which starts in the right inferior frontal gyrus and travels through the prefrontal cortex to the thalamus. Communication through this pathway is often disrupted in the brains of smokers. The researchers wanted to know if this pathway was involved when smokers attempted to quit.

The work began when Froeliger was a postdoctoral researcher in the laboratory of Joseph F. McClernon, Ph.D., at Duke University. The laboratory examined inhibitory control networks in the brains of 81 nicotine-dependent adults committed to trying a 10-week smoking cessation program. Before the program started, the researchers used functional MRI to monitor brain activity while patients were performing a task of inhibitory control. The patients were instructed to strike a computer key each time a colored circle appeared on screen, except on the rare occasion when a circle of a certain color appeared. A higher blood oxygenation level-dependent (BOLD) response in the inhibitory control circuit meant that the brain was using more resources to inhibit the automatic response of striking the key when the rare circle appeared.

After 10 weeks, about half of the smokers had quit successfully. Intriguingly, it turned out that they had lower BOLD responses in their inhibitory control networks before trying to quit. In particular, BOLD responses were lower in the right inferior frontal gyrus and right thalamus. They also had stronger functional connections between those regions. Patients who relapsed had scored just as well on the inhibition control task as those who quit successfully. It seemed that their automated behavior may have required more effort to inhibit.

Froeliger continued the work with a new twist when he became faculty at MUSC. He wondered if the same thing happened to smokers who had not committed to quitting. Specifically, could this pattern appear in smokers who were paid to quit for just an hour?

The group measured BOLD signals in 26 smokers performing the same task. This time, however, each person was then presented with an open pack of their preferred brand of cigarettes, a lighter, and an ashtray. They were paid one dollar for every six minutes they did not smoke, up to an hour. The idea was to give each person a small incentive to resist the temptation to smoke.

The results converged nicely. In general, the lower the BOLD response during the task of inhibitory control, the longer the person resisted smoking. Those who resisted temptation longer also had stronger functional connections in their inhibitory control networks.

Image shows the location of the thalamus in the human brain.

One way the brain inhibits automated behavior is through a pathway called the inhibitory control network, which starts in the right inferior frontal gyrus and travels through the prefrontal cortex to the thalamus. The location of the thalamus is highlighted in the MRI image. NeuroscienceNews.com image is credited to Čeština and is for illustrative purposes only.

This study is the first to link the strength of communication in a brain circuit that inhibits automated behavior with the ability to resist smoking.

This does not mean that smoking itself is the cause of the differences the researchers observed. Rather, this study was designed to learn how to better help smokers who want to quit. Froeliger’s group is now evaluating the potential of certain behavioral and pharmacological treatments that could strengthen communication in the inhibitory control pathway of people who smoke.

This work highlights that differences in biology can help explain why some smokers who are trying to resist smoking have more success than others.

“There are neurobiological mechanisms that are fundamental to learning new behaviors and also to stopping those that become automated, such as smoking,” said Froeliger.

About this psychology research article

Funding: The study was funded by NIH/National Institute of Drug Abuse.

Source: Heather Woolwine – Medical University of South Carolina
Image Source: NeuroscienceNews.com image is credited to Čeština and is licensed CC BY-SA 3.0.
Original Research: Abstract for “Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability” by Brett Froeliger, PhD; Patrick A. McConnell, MS1; Spencer Bell, BS; Maggie Sweitzer, PhD; Rachel V. Kozink, MS; Christie Eichberg, BS; Matt Hallyburton, BA; Nicole Kaiser, BA; Kevin M. Gray, MD; and F. Joseph McClernon, PhD in JAMA Psychiatry. Published online March 1 2017 doi:10.1001/jamapsychiatry.2017.0017

Cite This NeuroscienceNews.com Article
Medical University of South Carolina “Brain Circuit That Supports Smoking Cessation Identified.” NeuroscienceNews. NeuroscienceNews, 1 March 2017.
<http://neurosciencenews.com/neural-network-smoking-cessation-6175/>.
Medical University of South Carolina (2017, March 1). Brain Circuit That Supports Smoking Cessation Identified. NeuroscienceNew. Retrieved March 1, 2017 from http://neurosciencenews.com/neural-network-smoking-cessation-6175/
Medical University of South Carolina “Brain Circuit That Supports Smoking Cessation Identified.” http://neurosciencenews.com/neural-network-smoking-cessation-6175/ (accessed March 1, 2017).

Abstract

Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability

Importance Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferior frontal gyrus (IFG)—one node in a corticothalamic inhibitory control (IC) network.

Objective To examine associations between IC neural circuitry structure and function and lapse/relapse vulnerability in 2 independent studies of adult smokers.

Design, Setting, and Participants In study 1, treatment-seeking smokers (n = 81) completed an IC task during functional magnetic resonance imaging (fMRI) before making a quit attempt and then were followed up for 10 weeks after their quit date. In study 2, a separate group of smokers (n = 26) performed the same IC task during fMRI, followed by completing a laboratory-based smoking relapse analog task. Study 1 was performed at Duke University Medical Center between 2008 and 2012; study 2 was conducted at the Medical University of South Carolina between 2013 and 2016.

Main Outcomes and Measures Associations between corticothalamic-mediated IC, gray-matter volume, and smoking lapse/relapse.

Results Of the 81 study participants in study 1 (cessation study), 45 were women (56%), with mean (SD) age, 38.4 (10.2) years. In study 1, smoking relapse was associated with less gray-matter volume (F1,74 = 28.32; familywise error P threshold = 0.03), greater IC task-related blood oxygenation level–dependent (BOLD) response in the right IFG (F1,78 = 14.87) and thalamus (F1,78 = 14.97) (P < .05), and weaker corticothalamic task-based functional connectivity (tbFC) (F1,77 = 5.87; P = .02). Of the 26 participants in study 2 (laboratory study), 15 were women (58%), with mean (SD) age, 34.9 (10.3). Similar to study 1, in study 2, greater IC-BOLD response in the right IFG (t23 = −2.49; β = −0.47; P = .02), and weaker corticothalamic tbFC (t22 = 5.62; β = 0.79; P < .001) were associated with smoking sooner during the smoking relapse-analog task. In both studies, corticothalamic tbFC mediated the association between IC performance and smoking outcomes.

Conclusions and Relevance In these 2 studies, baseline differences in corticothalamic circuitry function were associated with mediated IC and smoking relapse vulnerability. These findings warrant further examination of interventions for augmenting corticothalamic neurotransmission and enhancing IC during the course of tobacco use disorder treatment.

“Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability” by Brett Froeliger, PhD; Patrick A. McConnell, MS1; Spencer Bell, BS; Maggie Sweitzer, PhD; Rachel V. Kozink, MS; Christie Eichberg, BS; Matt Hallyburton, BA; Nicole Kaiser, BA; Kevin M. Gray, MD; and F. Joseph McClernon, PhD in JAMA Psychiatry. Published online March 1 2017 doi:10.1001/jamapsychiatry.2017.0017

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