Researchers are using a mathematical tool to help determine which concussion patients will go on to suffer migraine headaches, according to a new study published online in the journal Radiology.Post-traumatic migraine headaches are common in people who suffer concussions. In recent years, researchers have been using diffusion tensor imaging, a type of MRI, to assess concussion-related damage to the brain’s signal-transmitting white matter and look for associations with symptoms like headaches. MRI can be used to create a frequency distribution graph of the whole brain called a histogram, and from that a mean fractional anistropy (FA), a measure of how easily water moves through the brain, can be derived to assess white matter injury. However, mean FA has shortcomings.“Mean FA represents an average,” said study author Lea M. Alhilali, M.D., from the University of Pittsburgh Medical Center in Pittsburgh. “If someone has a higher FA to begin with and they lose white matter integrity from trauma, they still might average out to have a normal mean FA.”Instead, the researchers analyzed the MRI results using information theory, a branch of mathematics based on mathematical laws surrounding the behavior of data as it is retrieved, transferred or stored. Shannon entropy, an information theory model that looks at areas of entropy, or disorder, in a complex system like the brain, has advantages over mean FA in the analysis of brain histograms, according to Dr. Alhilali.“A healthy brain has high entropy, but people with injuries to the white matter from trauma may lose some of that complexity and have less entropy,” she explained.In the first study of its kind, Dr. Alhilali and colleagues assessed the performance of Shannon entropy as a diagnostic tool in concussion patients with and without post-traumatic migraines.They obtained FA maps and neurocognitive testing results in 74 concussion patients, including 57 with post-traumatic migraines and 17 without. FA maps were obtained in 22 healthy controls and 20 control patients with migraine headaches for comparison. Mean FA and Shannon entropy were extracted from total brain FA histograms and compared between concussion patients and controls and between those with and without post-traumatic migraine.Shannon entropy analysis of FA histograms performed better than mean FA as a diagnostic test to differentiate between concussion patients and controls and also performed better in determining which concussion patients developed post-traumatic migraines. The concussion patients had significantly lower Shannon entropy compared to controls, and those with post-traumatic migraines had significantly lower Shannon entropy than other concussion patients. Patients with Shannon entropy below 0.750 were approximately 16 times more likely to have experienced concussion and three times more likely to develop post-traumatic migraines.Histogram of the time to presentation for patients with mild traumatic brain injury (mTBI) shows that the majority of the patients (83 percent) presented within 2 months of injury. The remaining nine patients with mTBI presented more than 12 weeks after the initial injury. Credit: RSNA.Shannon entropy inversely correlated with time to recovery, meaning that people with lower entropy took longer to recover.The results suggest that Shannon entropy may provide a convenient, reproducible biomarker that can be calculated in automated fashion to help triage patients after initial injury and predict which ones will go on to get more severe symptoms.“This approach requires just one histogram for the entire brain,” Dr. Alhilali said. “If it continues to show promise, then it could be added to the regular brain MRI as part of the study.”[divider]About this concussion research[/divider]Additional research is needed to study other potential applications of Shannon entropy, Dr. Alhilali said, such as predicting future cognitive performance in concussion patients.Source: Linda Brooks – RSNA Image Source: The image is credited to RSNA Original Research: Full open access research for “White Matter Injuries in Mild Traumatic Brain Injury and Posttraumatic Migraines: Diffusion Entropy Analysis” by Joseph Delic, Lea M. Alhilali, Marion A. Hughes, Serter Gumus, and Saeed Fakhran in Radiology. Published online February 1 2016 doi:10.1148/radiol.2015151388AbstractSee alsoAutismFeaturedNeuroscience·April 27, 2020Vasopressin levels could be a potential biomarker for autism in babiesWhite Matter Injuries in Mild Traumatic Brain Injury and Posttraumatic Migraines: Diffusion Entropy AnalysisPurpose To determine the performance of Shannon entropy (SE) as a diagnostic tool in patients with mild traumatic brain injury (mTBI) with posttraumatic migraines (PTMs) and those without PTMs on the basis of analysis of fractional anisotropy (FA) maps.Materials and Methods The institutional review board approved this retrospective study, with waiver of informed consent. FA maps were obtained and neurocognitive testing was performed in 74 patients with mTBI (57 with PTM, 17 without PTM). FA maps were obtained in 22 healthy control subjects and in 20 control patients with migraine headaches. Mean FA and SE were extracted from total brain FA histograms and were compared between patients with mTBI and control subjects and between patients with and those without PTM. Mean FA and SE were correlated with clinical variables and were used to determine the areas under the receiver operating characteristic curve (AUCs) and likelihood ratios for mTBI and development of PTM.Results Patients with mTBI had significantly lower SE (P < .001) and trended toward lower mean FA (P = .07) compared with control subjects. SE inversely correlated with time to recovery (TTR) (r = −0.272, P = .02). Patients with mTBI with PTM had significantly lower SE (P < .001) but not mean FA (P = .15) than did other patients with mTBI. SE provided better discrimination between patients with mTBI and control subjects than mean FA (AUC = 0.92; P = .01), as well as better discrimination between patients with mTBI with PTM and those without PTM (AUC = 0.85; P < .001). SE of less than 0.751 resulted in a 16.1 increased likelihood of having experienced mTBI and a 3.2 increased likelihood of developing PTM.Conclusion SE more accurately reveals mTBI than mean FA, more accurately reveals those patients with mTBI who develop PTM, and inversely correlates with TTR.“White Matter Injuries in Mild Traumatic Brain Injury and Posttraumatic Migraines: Diffusion Entropy Analysis” by Joseph Delic, Lea M. Alhilali, Marion A. Hughes, Serter Gumus, and Saeed Fakhran in Radiology. Published online February 1 2016 doi:10.1148/radiol.2015151388[divider]Feel free to share this neuroscience article.[/divider]Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. 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