Summary: Researchers have mapped structural changes that occur during development in the teenage brain and provide an explanation as to how some of these changes may predict mental health problems that can occur during late adolescence.
Source: University of Cambridge.
Scientists have mapped the structural changes that occur in teenagers’ brains as they develop, showing how these changes may help explain why the first signs of mental health problems often arise during late adolescence.
In a study published today in the Proceedings of the National Academy of Sciences, researchers from the University of Cambridge and University College London (UCL) used magnetic resonance imaging (MRI) to study the brain structure of almost 300 individuals aged 14-24 years old.
By comparing the brain structure of teenagers of different ages, they found that during this important period of development, the outer regions of the brain, known as the cortex, shrink in size, becoming thinner. However, as this happens, levels of myelin – the sheath that ‘insulates’ nerve fibres, allowing them to communicate efficiently – increase within the cortex.
Previously, myelin was thought mainly to reside in the so-called ‘white matter’, the brain tissue that connects areas of the brain and allows for information to be communicated between brain regions. However, in this new study, the researchers show that it can also be found within the cortex, the ‘grey matter’ of the brain, and that levels increase during teenage years. In particular, the myelin increase occurs in the ‘association cortical areas’, regions of the brain that act as hubs, the major connection points between different regions of the brain network.
Dr Kirstie Whitaker from the Department of Psychiatry at the University of Cambridge, the study’s first author, says: “During our teenage years, our brains continue to develop. When we’re still children, these changes may be more dramatic, but in adolescence we see that the changes refine the detail. The hubs that connect different regions are becoming set in place as the most important connections strengthen. We believe this is where we are seeing myelin increasing in adolescence.”
The researchers compared these MRI measures to the Allen Brain Atlas, which maps regions of the brain by gene expression – the genes that are ‘switched on’ in particular regions. They found that those brain regions that exhibited the greatest MRI changes during the teenage years were those in which genes linked to schizophrenia risk were most strongly expressed.
“Adolescence can be a difficult transitional period and it’s when we typically see the first signs of mental health disorders such as schizophrenia and depression,” explains Professor Ed Bullmore, Head of Psychiatry at Cambridge. “This study gives us a clue why this is the case: it’s during these teenage years that those brain regions that have the strongest link to the schizophrenia risk genes are developing most rapidly.
“As these regions are important hubs that control how regions of our brain communicate with each other, it shouldn’t be too surprising that when something goes wrong there, it will affect how smoothly our brains work. If one imagines these major hubs of the brain network to be like international airports in the airline network, then we can see that disrupting the development of brain hubs could have as big an impact on communication of information across the brain network as disruption of a major airport, like Heathrow, will have on flow of passenger traffic across the airline network.”
The researchers are confident about the robustness of their findings as they divided their participants into a ‘discovery cohort’ of 100 young people and a ‘validation cohort’ of almost 200 young people to ensure the results could be replicated.
The study was funded by a Strategic Award from the Wellcome Trust to the Neuroscience in Psychiatry Network (NSPN) Consortium.
Dr Raliza Stoyanova in the Neuroscience and Mental Health team at Wellcome, which funded the study, comments: “A number of mental health conditions first manifest during adolescence. Although we know that the adolescent brain undergoes dramatic structural changes, the precise nature of those changes and how they may be linked to disease is not understood.
“This study sheds much needed light on brain development in this crucial time period, and will hopefully spark further research in this area, and tell us more about the origins of serious mental health conditions such as schizophrenia.”
Funding: Funded by Wellcome Trust.
Source: Craig Brierley – University of Cambridge
Image Source: This NeuroscienceNews.com image is in the public domain.
Original Research: Full open access research for “Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome” by Kirstie J. Whitaker, Petra E. Vértes, Rafael Romero-Garcia, František Váša, Michael Moutoussis, Gita Prabhu, Nikolaus Weiskopf, Martina F. Callaghan, Konrad Wagstyl, Timothy Rittman, Roger Tait, Cinly Ooi, John Suckling, Becky Inkster, Peter Fonagy, Raymond J. Dolan, Peter B. Jones, Ian M. Goodyer, the NSPN Consortium, and Edward T. Bullmore in PNAS. Published online July 25 2016 doi:10.1073/pnas.1601745113
[cbtabs][cbtab title=”MLA”]University of Cambridge. “Changes in Teen Brain Structure Provide Clues to Onset of Mental Health Problems.” NeuroscienceNews. NeuroscienceNews, 26 July 2016.
<https://neurosciencenews.com/psychology-teen-brain-structure-4736/>.[/cbtab][cbtab title=”APA”]University of Cambridge. (2016, July 26). Changes in Teen Brain Structure Provide Clues to Onset of Mental Health Problems. NeuroscienceNew. Retrieved July 26, 2016 from https://neurosciencenews.com/psychology-teen-brain-structure-4736/[/cbtab][cbtab title=”Chicago”]University of Cambridge. “Changes in Teen Brain Structure Provide Clues to Onset of Mental Health Problems.” https://neurosciencenews.com/psychology-teen-brain-structure-4736/ (accessed July 26, 2016).[/cbtab][/cbtabs]
Abstract
Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome
How does human brain structure mature during adolescence? We used MRI to measure cortical thickness and intracortical myelination in 297 population volunteers aged 14–24 y old. We found and replicated that association cortical areas were thicker and less myelinated than primary cortical areas at 14 y. However, association cortex had faster rates of shrinkage and myelination over the course of adolescence. Age-related increases in cortical myelination were maximized approximately at the internal layer of projection neurons. Adolescent cortical myelination and shrinkage were coupled and specifically associated with a dorsoventrally patterned gene expression profile enriched for synaptic, oligodendroglial- and schizophrenia-related genes. Topologically efficient and biologically expensive hubs of the brain anatomical network had greater rates of shrinkage/myelination and were associated with overexpression of the same transcriptional profile as cortical consolidation. We conclude that normative human brain maturation involves a genetically patterned process of consolidating anatomical network hubs. We argue that developmental variation of this consolidation process may be relevant both to normal cognitive and behavioral changes and the high incidence of schizophrenia during human brain adolescence.
“Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome” by Kirstie J. Whitaker, Petra E. Vértes, Rafael Romero-Garcia, František Váša, Michael Moutoussis, Gita Prabhu, Nikolaus Weiskopf, Martina F. Callaghan, Konrad Wagstyl, Timothy Rittman, Roger Tait, Cinly Ooi, John Suckling, Becky Inkster, Peter Fonagy, Raymond J. Dolan, Peter B. Jones, Ian M. Goodyer, the NSPN Consortium, and Edward T. Bullmore in PNAS. Published online July 25 2016 doi:10.1073/pnas.1601745113
