Summary: A recent study reveals that specific brain cells respond not only to smells but also to images and written words related to those scents, providing deeper insight into human odor perception. Researchers found that neurons in the olfactory cortex and other brain regions, like the hippocampus and amygdala, distinguish between different smells and associate them with visual cues.
This research, using data from epilepsy patients, bridges a gap between animal and human studies on olfactory processing. Remarkably, individual neurons responded to scent, image, and word, suggesting that smell processing integrates visual and semantic information early on. These findings could lead to future innovations in “olfactory aids.” The study emphasizes the interconnected nature of smell and visual memory in the human brain.
Key Facts
- Neurons in the olfactory cortex respond to smells, images, and words alike.
- The study found the amygdala differentiates between pleasant and unpleasant odors.
- This research bridges knowledge gaps in human and animal olfactory processing studies.
Source: University of Bonn
We often only realize how important our sense of smell is when it is no longer there: food hardly tastes good, or we no longer react to dangers such as the smell of smoke.
Researchers at the University Hospital Bonn (UKB), the University of Bonn and the University of Aachen have investigated the neuronal mechanisms of human odor perception for the first time. Individual nerve cells in the brain recognize odors and react specifically to the smell, the image and the written word of an object, for example a banana.
The results of this study close a long-standing knowledge gap between animal and human odor research and have now been published in the renowned journal Nature.
Imaging techniques such as functional magnetic resonance imaging (fMRI) have previously revealed which regions of the human brain are involved in olfactory perception. However, these methods do not allow the sense of smell to be investigated at the fundamental level of individual nerve cells.
“Therefore, our understanding of odor processing at the cellular level is mainly based on animal studies, and it has not been clear to what extent these results can be transferred to humans,” says co-corresponding author Prof. Florian Mormann from the Department of Epileptology at the UKB, who is also a member of the Transdisciplinary Research Area (TRA) “Life & Health” at the University of Bonn.
Nerve cells in the brain identify odors
Prof. Mormann’s research group has now succeeded for the first time in recording the activity of individual nerve cells during smelling.
This was only possible because the researchers worked together with patients from the Clinic for Epileptology at the UKB, one of the largest epilepsy centers in Europe, who had electrodes implanted in their brains for diagnostic purposes. They were presented with both pleasant and unpleasant scents, such as old fish.
“We discovered that individual nerve cells in the human brain react to odors. Based on their activity, we were able to precisely predict which scent was being smelled,” says first author Marcel Kehl, a doctoral student at the University of Bonn in Prof. Mormann’s working group at the UKB.
The measurements showed that different brain regions such as the primary olfactory cortex, anatomically known as the piriform cortex, and also certain areas of the medial temporal lobe, specifically the amygdala, the hippocampus and the entorhinal cortex, are involved in specific tasks.
While the activity of nerve cells in the olfactory cortex most accurately predicted which scent was smelled, neuronal activity in the hippocampus was able to predict whether scents were correctly identified.
Only nerve cells in the amygdala, a region involved in emotional processing, reacted differently depending on whether a scent was perceived as pleasant or unpleasant.
Nerve cells react to the smell, image and name of the banana
In a next step, the researchers investigated the connection between the perception of scents and images. To do this, they presented the participants in the Bonn study with the matching images for each odor, for example the scent and later a photo of a banana, and examined the reaction of the neurons. Surprisingly, nerve cells in the primary olfactory cortex responded not only to scents, but also to images.
“This suggests that the task of the human olfactory cortex goes far beyond the pure perception of odors,” says co-corresponding author Prof. Marc Spehr from the Institute of Biology II at RWTH Aachen University.
The researchers discovered individual nerve cells that reacted specifically to the smell, the image and the written word of – for example – the banana. This discovery indicates that semantic information are processed early on in human olfactory processing.
The results not only confirm decades of animal studies, but also show how different brain regions are involved in specific human odor processing functions.
“This is an important contribution on the way to decoding the human olfactory code,” says Prof. Mormann.
“Further research in this area is necessary in order to one day develop olfactory aids that we can use in everyday life as naturally as glasses or hearing aids.”
Funding: The study was funded by the German Research Foundation (DFG), the Federal Ministry of Education and Research (BMBF) and the state of North Rhine-Westphalia (NRW) as part of the iBehave project.
About this olfaction and visual neuroscience research news
Author: Inka Väth
Source: University of Bonn
Contact: Inka Väth – University of Bonn
Image: The image is credited to Neuroscience News
Original Research: Open access.
“Single-neuron representations of odours in the human brain” by Florian Mormann et al. Nature
Abstract
Single-neuron representations of odours in the human brain
Olfaction is a fundamental sensory modality that guides animal and human behaviour. However, the underlying neural processes of human olfaction are still poorly understood at the fundamental—that is, the single-neuron—level.
Here we report recordings of single-neuron activity in the piriform cortex and medial temporal lobe in awake humans performing an odour rating and identification task. We identified odour-modulated neurons within the piriform cortex, amygdala, entorhinal cortex and hippocampus.
In each of these regions, neuronal firing accurately encodes odour identity. Notably, repeated odour presentations reduce response firing rates, demonstrating central repetition suppression and habituation.
Different medial temporal lobe regions have distinct roles in odour processing, with amygdala neurons encoding subjective odour valence, and hippocampal neurons predicting behavioural odour identification performance.
Whereas piriform neurons preferably encode chemical odour identity, hippocampal activity reflects subjective odour perception.
Critically, we identify that piriform cortex neurons reliably encode odour-related images, supporting a multimodal role of the human piriform cortex.
We also observe marked cross-modal coding of both odours and images, especially in the amygdala and piriform cortex. Moreover, we identify neurons that respond to semantically coherent odour and image information, demonstrating conceptual coding schemes in olfaction.
Our results bridge the long-standing gap between animal models and non-invasive human studies and advance our understanding of odour processing in the human brain by identifying neuronal odour-coding principles, regional functional differences and cross-modal integration.
