Some senescent (zombie) cells are embedded in young, healthy tissue and promote normal repair from damage, researchers say.
Oxidative damage to telomeres can trigger cellular senescence. The findings could lead to the development of new therapeutics for healthy aging and to combat cancers.
According to researchers, obese mice have increased levels of senescent cells in their brains, and these cells contribute to anxiety. Using senolytics to clear the cells helps to reduce anxiety related behaviors.
Researchers report senescent, or Zombie, cells accumulate in certain neurons prior to cognitive loss. By preventing accumulation of these cells, researchers were able to diminish apoptosis, memory loss and tau aggregation.