A small molecular compound has been discovered that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma brain cancer, making tumors more responsive to therapies.
Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.
A new study reports salt could be a possible trigger for inflammation in multiple sclerosis. Researchers report cells in a high salt environment show activation of the beta catenin/Wnt signaling pathway, a pathway previously implicated in disrupting regulatory T cells and triggering inflammation.
A new study reveals subplate cells may not simply disappear, they may, instead, be migrating to different levels of the cortex. In essence, subplate cells may become part of the cerebral cortex.
NIH researchers have identified a set of genes they believe could explain why some people need more, or less, sleep that others. The findings could help to develop new treatments for a variety of sleep disorders from insomnia to narcolepsy.
According to researchers, a mutation in a gene associated with brain development may dispose people to various psychiatric illnesses as it reduces synapse numbers. Lithium may help to restore some of the synapses.
Three subgroups of medulloblastoma brain cancer can be identified non-invasively using MRS neuroimaging technology.
A new study reports neurons in the eye alter on a molecular level when they are exposed to light for prolonged periods of time.