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weight loss

·May 22, 2026·8 min read

Study Aims to Break GLP-1 Weight-Loss Plateaus

The weight-loss effects of semaglutide depend on boosting a signaling molecule called cAMP within appetite-regulating neurons in the area postrema.

Featured Neuroscience

·May 12, 2026·7 min read

GLP-1 Drugs Dramatically Reduce “Food Noise” in Weight Loss

GLP-1 medications effectively "turn down the volume" on intrusive food thoughts. In a study of 417 adults, those combining medication with behavioral therapy saw a significantly greater reduction in "food noise" than those using therapy alone, offering a potential neurobiological explanation for the success of these new obesity treatments.

This shows a woman on a scale with people pointing at her.

Featured Neuroscience Psychology

·April 17, 2026·8 min read

Decoding the Shame Associated with Ozempic Weight Loss

Women using GLP-1 drugs for weight loss face higher levels of stigma than those using diet and exercise, with many critics viewing the medication as a "shortcut."

Featured Genetics Neuroscience

·April 8, 2026·8 min read

Ozempic Weight Loss Success Varies by DNA

A new study of 28,000 people identifies genetic markers in the GLP1R and GIPR genes that explain why some patients lose more weight or experience more nausea on GLP-1 drugs.

Featured Neuroscience Psychology

·March 26, 2026·7 min read

Repetition is Key: Eating the Same Meals Speeds Up Weight Loss

A 12-week study shows that repeating the same meals leads to greater weight loss. By reducing decision fatigue, "routinized eating" helps people lose 5.9% of their body weight compared to 4.3% for those eating varied diets.

Featured Neuroscience

·March 10, 2026·13 min read

Why GLP-1 Drugs Affect Men and Women Differently

A new atlas reveals that GLP-1—the backbone of blockbuster weight-loss drugs—is mapped differently in the male and female brain.

This illustration shows a brain on top of a weighting scale, representing the neural pathway associated with weight loss.

Featured Neuroscience

·February 15, 2026·7 min read

Newly Discovered Brain Pathway Triggers Weight Loss

Scientists have found a "master switch" in the brain that can trigger the rapid elimination of body fat, even while maintaining a normal diet.

This shows metabolic pathways in the brain.

Featured Neurology Neuroscience

·February 13, 2026·9 min read

Parkinson’s Triggers a Hidden Metabolic Shift

Think Parkinson's weight loss is just about nutrition? New research shows it’s actually a sign of an internal energy engine failure. By switching to a fat-burning "emergency engine," the body tries to compensate for a brain in crisis, making thinness a vital biological warning sign.

Featured Neuroscience

·November 17, 2025·9 min read

How Mounjaro Alters Craving Circuits in the Brain

A rare intracranial brain-recording study revealed that tirzepatide, a GLP-1 and GIP receptor agonist, temporarily silences craving-related neural activity in a key reward circuit of the brain. Using implanted electrodes in a patient with treatment-resistant obesity and loss of control eating, researchers observed that the drug initially shut down signaling in the nucleus accumbens.

This shows two people and symbols representing weight loss and aging.

Featured Neuroscience

·May 29, 2025·4 min read

Long-Term Weight Loss in Midlife Tied to Lifespan Benefits

A long-term study of 23,000 adults from Finland and the UK has found that overweight individuals who lost just 6.5% of their body weight in early midlife and maintained the loss enjoyed significant health benefits over decades. The study, spanning 12 to 35 years, is one of the first to link modest, sustained weight loss with lower mortality outside the context of diabetes prevention.

Featured Neuroscience

·May 26, 2025·4 min read

Brainstem Neurons Hold Key to Semaglutide’s Weight Loss Effects

Researchers have identified a specific group of brainstem neurons that mediate the appetite-reducing and weight-loss effects of semaglutide without triggering side effects like nausea. In mice, activating these neurons led to reduced food intake and fat loss, mimicking the drug’s benefits.

Featured Neuroscience

·May 13, 2025·6 min read

Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Trial

In a 72-week clinical trial, tirzepatide (Zepbound) led to significantly greater weight loss than semaglutide (Wegovy), with participants losing an average of 20.2% of their body weight versus 13.7%. The study directly compared the two drugs at their highest doses in people with obesity but without diabetes.