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          weight loss

          This shows a brain.
          FeaturedNeuroscience
          ·November 17, 2025·9 min read

          How Mounjaro Alters Craving Circuits in the Brain

          A rare intracranial brain-recording study revealed that tirzepatide, a GLP-1 and GIP receptor agonist, temporarily silences craving-related neural activity in a key reward circuit of the brain. Using implanted electrodes in a patient with treatment-resistant obesity and loss of control eating, researchers observed that the drug initially shut down signaling in the nucleus accumbens.
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          This shows two people and symbols representing weight loss and aging.
          FeaturedNeuroscience
          ·May 29, 2025·4 min read

          Long-Term Weight Loss in Midlife Tied to Lifespan Benefits

          A long-term study of 23,000 adults from Finland and the UK has found that overweight individuals who lost just 6.5% of their body weight in early midlife and maintained the loss enjoyed significant health benefits over decades. The study, spanning 12 to 35 years, is one of the first to link modest, sustained weight loss with lower mortality outside the context of diabetes prevention.
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          This shows a brain and food.
          FeaturedNeuroscience
          ·May 26, 2025·4 min read

          Brainstem Neurons Hold Key to Semaglutide’s Weight Loss Effects

          Researchers have identified a specific group of brainstem neurons that mediate the appetite-reducing and weight-loss effects of semaglutide without triggering side effects like nausea. In mice, activating these neurons led to reduced food intake and fat loss, mimicking the drug’s benefits.
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          This shows the outline of two people.
          FeaturedNeuroscience
          ·May 13, 2025·6 min read

          Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Trial

          In a 72-week clinical trial, tirzepatide (Zepbound) led to significantly greater weight loss than semaglutide (Wegovy), with participants losing an average of 20.2% of their body weight versus 13.7%. The study directly compared the two drugs at their highest doses in people with obesity but without diabetes.
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          This shows a woman surrounded by DNA.
          FeaturedGeneticsNeuroscience
          ·October 10, 2024·4 min read

          14 “Skinny” Genes Linked to Enhanced Weight Loss

          A recent study identifies 14 genes linked to enhanced weight loss when combined with moderate exercise, such as running for 30 minutes three times a week. Participants with the highest number of these "skinny genes" lost up to 5kg over eight weeks, while others lost about 2kg. One gene, PARGC1A, emerged as particularly influential, accounting for 62% of weight lost in participants, with the rest attributed to exercise and lifestyle factors. The study emphasizes that while genetics play a role, lifestyle changes are essential for optimal results. The findings could pave the way for personalized health and fitness interventions based on genetic profiles. This research supports the need for a balanced approach, combining genetics with exercise and diet for best outcomes.
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          This shows cereal
          FeaturedNeuroscience
          ·October 8, 2024·3 min read

          Sex-Based Breakfast Choices May Boost Metabolism

          A recent study using mathematical models suggests that breakfast choices may affect men’s and women’s metabolisms differently. Results indicate that men’s metabolisms respond better to carb-heavy breakfasts, while women’s bodies benefit more from higher-fat options like eggs or avocados, especially after fasting.
          Read More
          This shows a woman on a scale.
          FeaturedGeneticsNeuroscience
          ·July 15, 2024·5 min read

          Adjusting Proteins Increases Ozempic’s Effectiveness

          Adjusting melanocortin proteins in the brain enhances the effectiveness of GLP-1 diabetes and weight-loss drugs. By inhibiting MC3R or activating MC4R, mice showed increased sensitivity to these drugs, leading to more significant weight loss and reduced feeding without additional side effects.
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          This shows a woman in workout clothing and a scale.
          FeaturedNeuroscience
          ·June 8, 2024·4 min read

          Intense Exercise May Sabotage Weight Loss Efforts

          Intense exercise can reduce subsequent physical activity and body temperature, potentially leading to weight gain. The research, conducted on mice, suggests this effect is due to disruptions in the circadian rhythm of the stress hormone corticosterone.
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          This shows a woman under a UV light.
          FeaturedNeuroscience
          ·May 22, 2024·5 min read

          UV Light Increases Appetite But Suppresses Weight Gain

          A new study reveals that UV exposure can increase appetite while simultaneously preventing weight gain. This unexpected finding is attributed to UV's influence on hormones and neurotransmitters, leading to increased energy expenditure and the browning of subcutaneous fat. These insights could pave the way for innovative approaches to combat obesity and metabolic disorders.
          Read More
          This shows a woman and measuring tape.
          FeaturedNeuroscience
          ·May 16, 2024·6 min read

          GLP-1 and NMDA Targeted Weight-Loss Drug Shows Promise

          Researchers have developed a novel weight-loss drug that combines GLP-1 with molecules targeting NMDA receptors in the brain. This "Trojan Horse" approach allows the drug to specifically target the appetite control center, leading to significant weight loss in mice.
          Read More
          This shows an empty plate.
          FeaturedNeuroscience
          ·March 1, 2024·4 min read

          What Happens to the Body During Prolonged Fasting?

          A new study illuminated the extensive molecular changes that occur in the body during prolonged fasting. Monitoring 12 healthy volunteers on a seven-day water-only fast, the study identified significant shifts in around 3,000 proteins across all major organs, with notable changes only becoming apparent after three days of fasting.
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          This shows a pair of running shoes.
          FeaturedNeuroscience
          ·February 20, 2024·4 min read

          Weekend Workouts Just as Effective for Weight Loss as Daily Exercise

          "Weekend warriors," or those who concentrate their physical activity into one or two days a week, can achieve weight loss comparable to that of individuals who exercise more frequently. This research, which utilizes objective measures of fat tissue mass, supports the idea that meeting the World Health Organization's physical activity recommendations, regardless of the frequency, is beneficial for reducing adiposity.
          Read More
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          This shows a brain.

          Blocking a Key Protein Greatly Reduces Alzheimer’s Damage

          This shows a head and a brain.

          Why Memories Change: How the Brain Rewrites the Past

          This shows a brain and a cigarette.

          Astrocytes Found to Drive Key Brain Changes in Nicotine Addiction

          This shows two people hugging.

          Warmth and Hugging Strengthen the Feeling of Being You

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