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SNMMI

·June 24, 2025·3 min read

PET Imaging Maps Brain Inflammation in Progressive Speech Disorder

A novel PET imaging study has identified unique patterns of neuroinflammation in patients with progressive apraxia of speech (PAOS), a rare disorder that impairs the brain’s ability to plan speech. Using TSPO PET scans, researchers found elevated inflammation in brain regions involved in movement and speech, particularly in patients who also showed signs of Parkinson-plus syndromes.

Featured Neurology Neuroscience

·June 24, 2025·3 min read

Neuroimaging Pinpoints Brain Inflammation

A newly developed PET radiotracer, ¹⁸F-PDE-1905, offers high-resolution imaging of neuroinflammation by targeting a key enzyme inside microglia, the brain’s immune cells. Unlike traditional tracers that target general downstream markers, this novel tracer hones in on PDE4B, a critical regulator of inflammatory signaling.

Featured Neuroscience

·March 28, 2025·4 min read

Dopamine Surge Boosts Brain’s Ability to Adapt

For the first time, researchers have directly observed dopamine release in the human brain during moments of cognitive flexibility. Using PET imaging, they found that dopamine levels spike in the ventromedial prefrontal cortex when people switch between tasks — and the more dopamine released, the more efficiently they adapted.

Featured Neuroscience

·June 27, 2023·3 min read

Obesity Alters Brain’s Response to Food Cues

New research using molecular imaging with 18F-flubatine PET/MRI shows a distinct response to food cues in the brains of obese individuals compared to those of normal-weight individuals. The study sheds light on the biological mechanisms of obesity and opens the door to potential targeted treatments.

Featured Neurology Neuroscience

·April 21, 2022·4 min read

Novel Deep Learning Method Provides Early and Accurate Differential Diagnosis for Parkinsonian Diseases

A new deep learning algorithm utilizes neuroimaging data to differentiate between Parkinson's disease and other parkinsonian syndromes such as PSP and multiple systems atrophy.

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Long-COVID Symptoms May Be Caused by Fatigue, Not Regional Brain Dysfunction

A new study reports long-term cognitive problems that occur following COVID-19 infection may be a result of fatigue rather than pathological alterations in the brain.

Featured Neurology

·July 15, 2020·4 min read

Super-Agers Show Resistance to Tau and Amyloid Accumulation

PET neuroimaging reveals super-agers and those whose cognitive skills are above the norm for an advanced age have an increased resistance to tau and amyloid proteins.