Some senescent (zombie) cells are embedded in young, healthy tissue and promote normal repair from damage, researchers say.
Oxidative damage to telomeres can trigger cellular senescence. The findings could lead to the development of new therapeutics for healthy aging and to combat cancers.
Hippocampal neurogenesis and cognitive function were improved in aging mice by destroying senescent cells in the aging stem cell niche.
Alterations associated with aging and cellular senescence may be linked to a decrease in cell proliferation, while cancer shifts towards increased cell division. The study challenges the traditional view that cancer risks increase as we age, finding the aging process may suppress the development of cancer.
Findings have applications for senolyics, the development of drugs that could eliminate aging cells.
According to researchers, obese mice have increased levels of senescent cells in their brains, and these cells contribute to anxiety. Using senolytics to clear the cells helps to reduce anxiety related behaviors.
Researchers report helping the immune system clear away old senescent cells in aging mice helped to restore youthful characteristics. The findings could have implications for reversing the effects of aging in humans.
A new study reports it is possible to reverse the effects of aging, at least on a cellular level. Researchers say molecules called senolytics can reverse the impact of aged, senescent cells.
Researchers report senescent, or Zombie, cells accumulate in certain neurons prior to cognitive loss. By preventing accumulation of these cells, researchers were able to diminish apoptosis, memory loss and tau aggregation.
A new study reports researchers have identified a possible new avenue for treating Parkinson's symptoms and neuropathology. Clearing senescent astrocytes appears to help prevent sporadic versions of the disease triggered by exposure to pesticides.
Researchers report a targeted removal of senescent cells could delay the onset of age related pathologies.
Removing senescent cells may help to reverse some of the signs of aging, researchers report.
