A new AI model mimics how the prefrontal cortex uses gating to control information flow between different areas of neurons. The system could help in the development of new artificial intelligence technologies that better mimic the human brain.
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.
Neural progenitor cells generated from skin cell samples of people on the autism spectrum had heightened levels of DNA damage. The damage clustered in 36 of the same genes which had also been damaged in healthy cells exposed to replication stress. Twenty of the genes have previously been linked to the development of autism.
CMS121 and J147, two drug candidates that improve memory and slow neurodegeneration associated with Alzheimer's disease, also slow aging in healthy, older mice. The compounds block damage to neurons caused by general aging and restore levels of specific molecules to those seen in younger animals.
Researchers have identified a comprehensive circuit mechanism that governs how emotional states can influence movement through connections in the basal ganglia. The mechanism represents a way in which emotional states relate to changes in action control in depression, anxiety, and OCD.