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Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·4 min read

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 29, 2019·3 min read

Could a small fish prompt a leap forward for Alzheimer’s disease research?

Using zebrafish models, researchers detected genes with altered levels of expression. The genetic variations were associated with abnormalities with mitochondrial function and the production of ATP.

Featured Neurology Neuroscience

·May 28, 2019·6 min read

High LDL cholesterol linked to early-onset Alzheimer’s

Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.

a brain with a drawing of a viral vector on top

Featured Genetics Neurology Open Neuroscience Articles

·June 21, 2018·10 min read

Viral Connection to Alzheimer’s: Herpes Virus Implicated in Alzheimer’s Disease

Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.

Featured Genetics Neurology Open Neuroscience Articles

·May 29, 2018·5 min read

Understanding the Origins of Alzheimer’s Disease

Researchers investigate the role the BMI1 gene plays in the onset and development of Alzheimer's disease. The study reports the loss of BMI1 triggers and increased production of amyloid beta and decreases neural ability to eliminate the protein.

Featured Neurology Neuroscience Open Neuroscience Articles

·November 17, 2017·4 min read

Astrocytes Linked to Alzheimer’s Disease

Researchers have discovered a direct association between astrocytes and Alzheimer's disease. In a new study, researchers report astrocytes in the brains of Alzheimer's patients produced significantly more amyloid beta than astrocytes in the brains of people without the disease.