Cryogenic-electron microscopy allowed researchers to determine the basic building blocks of prion proteins, including the placements of their amino acids.
Study reveals the surface features of human prions responsible for their replication in the brain. The findings provide a template to identify structurally important sites on other misfolded proteins, such as those associated with Alzheimer's disease.
Study sheds light on what causes normal proteins to convert to a diseased form associated with CJD and Kuru.
Self-propagating amyloid and tau act as prions in the pathology of Alzheimer's disease. Higher levels of the prions in human brain samples were strongly correlated with early onset of Alzheimer's and death at a younger age.
Researchers have developed a new skin biopsy test that can detect prion infections in skin samples before symptoms of disease appear.
Researchers have successfully created a synthetic version of a human prion, a protein associated with brain wasting diseases like sporadic Creutzfeldt-Jakob disease. The prions may help shed new light on, and provide treatment options, for those with CJD and other prion related diseases.
Researchers have detected a prion protein associated with CJD on the skin of almost two dozen people who died from the disease. The findings raise questions as to whether transmission of the disease via skin transplantation may be possible, and whether a simple skin test could detect the disease.
Researchers have uncovered the 3D structure of infectious prions.
Researchers report a protein normally associated with prion diseases may help to maintain myelin.
A new study reports on a newly discovered system that shows early toxicity to dendrtic spines.
A new assay offers improved sensitivity of current tests for transmissible spongiform encephalopathies, researchers report.
A new study looks at the toxicity and benefits of the use of anti-prion antibodies.
