Apremilast, an FDA-approved drug for the treatment of skin conditions including psoriasis and psoriatic arthritis, triggers increased activity in the nucleus accumbens, a brain area associated with regulating alcohol intake. Apremilast reduced drinking behaviors in mouse models with a genetic risk of alcohol use disorder.
Study identifies the synaptotagmin-3 (SYT3) protein as a key molecule that allows for synaptic transmission. The findings could help with the development of treatment for a range of neurological disorders including ASD and epilepsy.
For the first time, researchers have captured in near-atomic detail the structure of a key part of the inner ear responsible for hearing. The results could pave the way for developing new treatments for those with hearing impairments.
In veterans who suffered a TBI, lack of sleep was associated with enlarged perivascular spaces and an increase in post-concussive symptoms.
Study reveals a correlation between the composition of the gut microbiome and behavioral and cognitive performance in mice with Alzheimer's related genes.
Some of the T cell epitopes targeting myelin in monkeys were the same as those found in humans. Researchers say linking these specific cells opens the doors to developing antiviral therapies that could be useful to treat newly diagnosed cases of MS in humans.
A newly engineered compound prevents damage to myelin and nerve fibers by stimulating a protective response in cells that produce and maintain myelin. The compound has positive implications for the treatment of Multiple Sclerosis.
Hydroxychloroquine and azithromycin, two drugs touted as potential coronavirus therapeutics, could increase the risk of heart arrhythmias, cardiologists say.
Hikikomori, the condition of extreme social isolation, is more ubiquitous than previously believed. Researchers say modern tools to help improve interpersonal communication may have the opposite effect.
A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning.
New model could inform the development of new treatments for Lewy body diseases by targeting alpha-synuclein DNA repair mechanisms.
Combining infrared laser stimulation with ultra-high-field MRI, researchers revolutionize brain mapping.