opioids

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opioids

·January 13, 2023·6 min read

Scientists Take Another Step Toward Building a Better, Safer Opioid

Using cryoEM technology, researchers have decoded the detailed structures of an entire family of opioid receptors bound to their naturally occurring peptides. This new structural framework should help in the development of safer, more effective medications to treat chronic pain.

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Featured Neuroscience Psychology

·November 14, 2022·4 min read

Fentanyl Vaccine Potential ‘Game Changer’ for Opioid Epidemic

A newly developed vaccine blocks the ability of the opioid Fentanyl's ability to enter the brain, thus blocking the drug's "high".

This shows a brain slice with serotonin neurons in the Nca highlighted

Featured Neuroscience Psychology

·November 4, 2022·6 min read

Serotonin Key to Social Aversion During Withdrawal From Opioids

Opioid withdrawal cuts off the supply of serotonin to the nucleus accumbens, dramatically reducing sociability in mice and increasing social aversion.

This is a cartoon of a woman rubbing her back in pain

Featured Neurology Neuroscience Neuroscience Videos Pain

·September 25, 2022·4 min read

Could Monoclonal Antibodies Replace Opioids for Chronic Pain?

Researchers are developing a monthly monoclonal antibody therapy for the treatment and management of chronic pain. The hope is this new therapy can replace opioids for pain management.

Featured Neuroscience

·August 30, 2022·3 min read

Fentanyl’s Effects on the Brain

Fentanyl exposure produces specific EEG signatures in the brain. The findings also revealed the drug impairs people's breathing four minutes before noticeable changes in alertness.

Featured Neuroscience Pain

·August 15, 2022·5 min read

AI Could Help Patients With Chronic Pain Avoid Opioids

Cognitive behavioral therapy for pain that is supported by artificial intelligence renders the same results as guideline-recommended programs while requiring less clinician time, thus making the option more accessible for patients.

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·July 29, 2022·5 min read

Prenatal Opioid Exposure May Trigger Neurological and Behavioral Changes Later in Life

Opioids impact the gut microbiome of developing fetuses, altering metabolic pathways and increasing the risks of both neurological and behavioral differences later in life.

Featured Neuroscience Pain Psychology

·July 11, 2022·5 min read

Study Provides First Evidence of Link Between Opioid Use Disorder and Chronic Pain

Centralized sensation, or abnormal pain processing in the brain and spinal cord, may be an important underlying factor complicating the treatment of chronic pain in those with opioid use disorder.

Featured Neurology Neuroscience Pain

·June 21, 2022·5 min read

New Drugs With High Abuse Potential More Likely to Be Approved and Go to Market to Treat Pain

Study reveals 27.8% of pain medications with high abuse potential make it all the way through the development process, compared to only 4.7% of medications with lower potential for abuse.

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·June 14, 2022·4 min read

Fentanyl May Cause Autism-Like Behavior in Young Mice

Exposure to the opioid fentanyl induces autism-like behaviors in mice by activating mu-opioid receptors in the anterior cingulate cortex.

Featured Genetics Neuroscience

·August 15, 2021·4 min read

Brain Gene Expression Patterns Altered by Chronic Opioid Use

Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.

Featured Neuroscience Psychology

·July 26, 2021·4 min read

65+ and Lonely? Don’t Talk to Your Doctor About Another Prescription

Researchers say older adults who feel lonely are twice as likely to use opioids to control pain, and 2.5 times more likely to be prescribed anti-anxiety medications and sedatives than those who have a more socially active lifestyle.

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