A newly developed experimental vaccine can diminish the fatal respiratory effects of carfentanil and fentanyl in rodent models.
35% of patients who used ketamine to manage pain reported significant side effects ranging from hallucination, out-of-body experiences, visual disturbances, and urinary dysfunction. 20% of the side effects were linked directly to ketamine, and 15% associated with ketamine in combination with other drugs.
Opiate exposure causes synaptic rewiring in the nucleus accumbens in addition to decreasing dendritic spines. The findings shed light into the neurobiology of opiate relapse.
Inflammation caused by opioid use to both the brain and gut may exacerbate symptoms of negative emotions associated with withdrawal. Targeting the inflammation could help alleviate the negative experiences of opioid withdrawal and prevent dependence.
Almost 1 in 5 people now use opioids to treat migraines. Researchers say a growing number of patients are using opioids to replace medications approved and specially designed to treat migraines, despite knowing the risks of opioid use.
A new study clarifies the mechanism behind how ketamine works as an antidepressant. Researchers say there is evidence to suggest ketamine binds to NMDA receptors, instead of opioid receptors. Reducing the belief that ketamine is an opioid may make patients with depression more open to using the treatment.
SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.
Galantamine, a medication used to treat Alzheimer's disease, shows promise in helping break opioid addiction.