Researchers discover how sodium influences the signalling of opioid receptors.
35% of patients who used ketamine to manage pain reported significant side effects ranging from hallucination, out-of-body experiences, visual disturbances, and urinary dysfunction. 20% of the side effects were linked directly to ketamine, and 15% associated with ketamine in combination with other drugs.
Researchers have developed a new compound that selectively targets the brain's analgesic circuitry, but does not trigger potentially lethal side effects like traditional opioids.
A newly developed vaccine blocks the ability of the opioid Fentanyl's ability to enter the brain, thus blocking the drug's "high".
SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.
Researchers have developed a variant of the Mu opioid receptor which has several advantages for experimentation The variant can be grown in large quantities and is water soluble, allowing for experiments and applications which have previously been challenging.
Researchers have discovered chemical circuits and mechanisms in the brain that separate food consumption from cravings.
Researchers report 10 percent of people who have attended EDM events have misused opioids in the past 12 months. The number, researchers say, exceeds national averages. Oxycontin was reported to be the most widely misused drug within the scene.
Opioid withdrawal cuts off the supply of serotonin to the nucleus accumbens, dramatically reducing sociability in mice and increasing social aversion.
Alterations in long-term social behavior and gene expression were observed in the offspring of mice exposed to pain-killing opioids during pregnancy.