A new large-scale genome-wide study has identified 18 new genetic risk factors for opioid use disorder, bringing the number of OUD-associated genes from 1-19.
Centralized sensation, or abnormal pain processing in the brain and spinal cord, may be an important underlying factor complicating the treatment of chronic pain in those with opioid use disorder.
Opioid use disorder affects genes associated with proinflammatory immune molecule encoding and genes associated with remodeling the extracellular matrix, suggesting the connection between neurons may be altered as a result of opioid use. Additionally, those with OUD have higher levels of microglia in the brain.
Neuroinflammation may be a key player in the pathological brain changes produced as a result of chronic opioid use. Microglia is likely responsible for the majority of the changes.
Study reveals 412 counties, mainly in the Midwest and South, are at the highest risk of opioid deaths in the US. Researchers propose new strategies for improving treatment for opioid addiction.
CBD reduces craving and anxiety in those with heroin use disorder during withdrawal from the drug. There were no serious adverse reactions, or impairments to cognition noted with the administration of CBD. Researchers suggest cannabidiol may be useful in helping to combat opioid addiction.
The opioid epidemic is fueling a surge in infectious diseases such as HIV, hepatitis and soft tissue infections, researchers report.
