Bcl6 acts as a driver of neurogenic transition by directly silencing a selection of genes that belong to multiple extrinsic pathways promoting self-renewal. Bcl6 is only expressed in specific subsets of neurons and progenitor cells during brain development.
Researchers discover the protein nestin produced in astrocytes plays a role in inhibiting neural differentiation. The study reports nestin does not control adult neurogenesis by acting within neural stem cells, but by regulating Notch signals neural stem cells receive from astrocytes.
A new study in eLife reports lunatic fringe genes mediates a mechanism that preserves neural stem cells, so they can form new neurons throughout life. The findings, researchers say, have far-reaching implications for the study of neurogenesis.
Researchers report they have uncovered a gene responsible for brain development and also discovered how it may work.