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neuropharmacology

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·May 25, 2021·4 min read

Non-Hallucinogenic Psychedelic Analog Reverses Effects of Stress in Mice

A single dose of tabernanthalog (TBG), a non-hallucinogenic psychedelic analog, corrects stress-induced behavioral deficits, including anxiety and cognitive inflexibility, in mouse models. Additionally, the compound promoted neurogenesis and restores neural circuits in brain areas damaged by stress.

Featured Neurology Neuroscience

·May 24, 2021·3 min read

Step-Closer to Nasal Spray Drug Delivery for Parkinson’s Disease

A new gel that contains levodopa can adhere to nasal tissue. The gel releases levodopa directly into the blood and brain. Researchers say the preliminary data reveals the gel has proven to be effective in animal models.

Featured Genetics Neuroscience Psychology

·May 19, 2021·5 min read

Flies With Schizophrenia-Associated Genes Respond Well to Anti-Psychotics

Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.

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Brain Cancer Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 11, 2021·4 min read

Tumor-Promoting Immune Cells Retrained to Fight Most Aggressive Type of Brain Cancer

Combining αGITR antibodies with ICBs resulted in stronger survival benefits in mouse models of human glioblastoma brain cancer.

Featured Neuroscience Open Neuroscience Articles Psychology

·May 3, 2021·4 min read

Same Drug Can Have Opposite Effects on Memory Depending on Sex

Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.

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Featured Neuroscience Psychology

·April 6, 2021·4 min read

Resurging Psychedelic Therapies for Depression

As interest in using psychedelics to treat a range of mental health disorders grows, researchers consider the impact and therapeutic benefits of using psychedelics to help alleviate symptoms of depression.

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Brain Cancer Featured Neurology Neuroscience

·April 1, 2021·7 min read

Chemo for Glioblastoma May Work Better in Morning Than Evening

Administering the chemotherapy drug temozolomide to glioblastoma brain cancer patients in the morning may enhance the cancer-fighting effects. The study demonstrates the timing of chemotherapy could have a significant impact on treatment for glioblastoma patients.

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Brain Cancer Featured Neurology Neuroscience

·March 30, 2021·5 min read

Bespoke Neuroblastoma Therapy Weaponizes Cell Metabolism

Two existing medications show promise in the treatment of the deadly childhood cancer, neuroblastoma. Phenformin and AZD3965 exploit the metabolic hunger of the disease to kill cancer cells without inflicting excessive damage to healthy tissue.

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Featured Neurology Neuroscience

·March 27, 2021·4 min read

Common Alzheimer’s Treatment Linked to Slower Cognitive Decline

Cholinesterase inhibitors such as galantamine, donepezil, and rivastigmine, appear to generate persistent cognitive benefits, and increased longevity for up to five years in Alzheimer's patients.

Featured Neurology Neuroscience

·March 24, 2021·3 min read

Repurposed Drug Improves Cognition in Alzheimer’s Patients

Sargramostim, a medication that boosts white blood cells following cancer treatment, appears to improve memory and cognition in people with mild-to-moderate Alzheimer's disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 22, 2021·2 min read

Focusing on the Unhealthy Brain to Speed Drug Discovery

A new open-source tool-kit allows researchers to accelerate the discovery of drugs to treat a range of neurological disorders.

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Featured Neurology Neuroscience

·March 16, 2021·4 min read

Could Birth Control Pills Ease Concussion Symptoms in Female Athletes?

Birth control pills high in progesterone might be a new weapon in the fight against concussion in women. Researchers found that during the menstrual cycle, when progesterone levels were higher, women reported less concussion-related stress. Post-concussion stress reduction is a sign of recovery from a head injury. Progesterone is also linked to increased blood flow to the brain.