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neuropharmacology

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·January 20, 2025·6 min read

GLP-1 Drugs Offer Brain Benefits but May Pose Other Health Risks

A study analyzing data from over 2 million veterans found that GLP-1 receptor agonists, popular weight-loss drugs like Ozempic and Wegovy, provide significant neurological and behavioral health benefits, including reduced risks of addiction, Alzheimer’s, and dementia. However, they also pose risks for pancreatitis and kidney conditions, emphasizing the need for careful monitoring.

This shows a man's head and the covid virus.

Featured Neuroscience

·January 6, 2025·5 min read

Extended Paxlovid May Relieve Long Covid Symptoms

Extended courses of Paxlovid may alleviate symptoms in some patients with long Covid, though its effectiveness varies widely. Of 13 patients studied, five experienced sustained improvements, while others reported temporary or no benefits.

Featured Neurology Neuroscience

·January 3, 2025·5 min read

Ketamine Offers Hope for Parkinson’s Treatment-Linked Dyskinesia

Researchers have uncovered a new understanding of levodopa-induced dyskinesia, a common side effect in Parkinson’s patients, revealing that the motor cortex disconnects rather than directly causing these movements.

Featured Neurology Neuroscience

·November 26, 2024·3 min read

Alzheimer’s Drug Shrinks Brain Volume by Removing Amyloid Plaques

Brain volume loss linked to new Alzheimer’s immunotherapies, such as lecanemab, is caused by the removal of amyloid plaques rather than neuronal damage. Researchers analyzed data from multiple trials and coined the term "amyloid-removal-related pseudo-atrophy" (ARPA) to describe this phenomenon.

Featured Genetics Neurology Neuroscience

·November 25, 2024·4 min read

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.

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Featured Neurology Neuroscience

·November 21, 2024·5 min read

Parkinson’s Medication Alters Microbiome, Induces Iron Deficiency

The Parkinson's drug entacapone disrupts the gut microbiome by inducing iron deficiency, favoring the growth of potentially harmful bacteria like E. coli. Using advanced molecular techniques, researchers identified that entacapone interferes with iron availability, a critical resource for many gut microbes.

Featured Neurology Neuroscience

·November 18, 2024·4 min read

Repurposed Multiple Sclerosis Drug May Improve Memory

Fampridine, used for improving walking in multiple sclerosis, may also enhance working memory in individuals with schizophrenia or depression. A study found that the drug significantly improved working memory in participants with initially poor performance, but had no effect on those with strong baseline memory.

This shows a pregnant woman and a brain.

Featured Neurology Neuroscience

·November 15, 2024·5 min read

Antiseizure Drugs in Pregnancy Linked to Neurodevelopmental Risks

Research suggests that certain antiseizure medications taken during pregnancy may increase the risk of neurodevelopmental conditions in children. Drugs like valproate, topiramate, and carbamazepine were associated with specific risks, including autism and intellectual disability, while lamotrigine was found to pose little to no additional risk.

Featured Neurology Neuroscience

·November 7, 2024·4 min read

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Researchers have developed a promising nasal spray therapy targeting neuroinflammation in Alzheimer’s disease, potentially delaying its progression by over a decade. Using extracellular vesicles derived from neural stem cells, the treatment reduced inflammation and protein build-up in the brain in early-stage Alzheimer’s animal models.

Featured Neurology Neuroscience

·November 2, 2024·7 min read

Polymer Therapy Shows Promise Against Huntington’s Disease

Scientists have developed a novel polymer-based therapy that could slow Huntington's disease progression by preventing harmful protein clumps in the brain. In a mouse model, this polymer therapy effectively halted cell death, improved neuron health, and enhanced motor function.

This shows computer code and a molecule.

Featured Neuroscience

·October 24, 2024·6 min read

AI Predicts Chemical Compounds for Dual-Target Medications

Researchers have developed an AI system that predicts chemical compounds capable of targeting two proteins simultaneously, potentially creating more effective medications. By training the AI with a chemical language model, it was able to generate novel molecular structures with dual-target activity, an essential feature for treating complex diseases like cancer.

Featured Neurology Neuroscience

·October 23, 2024·5 min read

Penicillin Use Linked to Lower Parkinson’s Risk

A new study found that people who took multiple courses of penicillin antibiotics had a 15% lower risk of developing Parkinson's disease. Researchers analyzed medical records of over 93,000 individuals and discovered a connection between gut health and the disease, suggesting that altering the gut microbiome may influence Parkinson’s risk.

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neuropharmacology

GLP-1 Drugs Offer Brain Benefits but May Pose Other Health Risks

Extended Paxlovid May Relieve Long Covid Symptoms

Ketamine Offers Hope for Parkinson’s Treatment-Linked Dyskinesia

Alzheimer’s Drug Shrinks Brain Volume by Removing Amyloid Plaques

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

Parkinson’s Medication Alters Microbiome, Induces Iron Deficiency

Repurposed Multiple Sclerosis Drug May Improve Memory

Antiseizure Drugs in Pregnancy Linked to Neurodevelopmental Risks

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Polymer Therapy Shows Promise Against Huntington’s Disease

AI Predicts Chemical Compounds for Dual-Target Medications

Penicillin Use Linked to Lower Parkinson’s Risk

Omega-3 DHA Eases Autism Behaviors by Calming Inflammation

Neuromorphic Chip Decodes Brain’s Emotion Waves

How Video Gamers Make Split-Second Decisions

The Dark Side of Bonding With AI Companions

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