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neuropharmacology

·May 21, 2025·4 min read

New Alzheimer’s Drug Boosts Brain Protection, Restores Memory

Researchers have identified a promising drug candidate, DDL-357, that improves memory in Alzheimer’s mouse models by increasing levels of a protective brain protein called clusterin (CLU). CLU helps prevent the buildup of toxic amyloid-beta plaques and tau proteins, both key drivers of Alzheimer’s disease.

Featured Neurology Neuroscience Pain

·May 20, 2025·4 min read

Next-Gen Painkiller Blocks Pain Without the High

Summary: A new experimental drug, SBI-810, may deliver potent pain relief without the addictive and harmful side effects of opioids....

Featured Neuroscience

·May 18, 2025·3 min read

Vitamin B1 Derivative Sparks Dopamine, Boosts Wakefulness

Thiamine derivatives, once developed to treat nutrient deficiencies, are now being explored for their potential effects on brain function and energy. A new study shows that TTFD, a thiamine derivative, increases dopamine in the brain’s medial prefrontal cortex, leading to enhanced arousal and physical activity in rats.

Featured Neurology Neuroscience Pain

·May 17, 2025·4 min read

Tylenol Targets Pain Through Unexpected Endocannabinoid Pathway

A new study reveals that acetaminophen (Tylenol) relieves pain by reducing levels of an endocannabinoid called 2-AG, rather than increasing it as previously thought. This discovery challenges decades-old assumptions about how pain relief works and may open the door to designing safer, more targeted medications.

Brain Cancer Featured Neurology Neuroscience

·May 15, 2025·4 min read

Gabapentin Linked to Longer Survival in Glioblastoma Brain Cancer

A new study suggests that gabapentin, a widely used anti-seizure medication, may improve survival in patients with glioblastoma (GBM), the deadliest form of brain cancer. Researchers found that GBM patients taking gabapentin lived several months longer than those who did not, across two independent hospital datasets.

Featured Neuroscience

·May 13, 2025·6 min read

Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Trial

In a 72-week clinical trial, tirzepatide (Zepbound) led to significantly greater weight loss than semaglutide (Wegovy), with participants losing an average of 20.2% of their body weight versus 13.7%. The study directly compared the two drugs at their highest doses in people with obesity but without diabetes.

Brain Cancer Featured Neurology Neuroscience

·May 13, 2025·7 min read

CAR-T Brain Fog Mirrors Chemo and COVID

Patients receiving CAR-T cell therapy often report brain fog, and new research shows this cognitive impairment stems from the therapy itself, not just the cancer or other treatments. A mouse study revealed that CAR-T-induced immune responses activate brain microglia, triggering inflammation that damages myelin-producing cells, reducing signal efficiency in the brain.

Featured Neurology Neuroscience

·May 12, 2025·6 min read

Brain Wave Phase Locking May Be Key to Unconsciousness

Despite acting through different molecular mechanisms, ketamine and dexmedetomidine both disrupt brain wave phase alignment in ways that reliably induce unconsciousness. A new study reveals that these anesthetics trigger a common signature: increased phase locking at low frequencies, particularly between brain hemispheres, while disrupting local cortical communication.

Featured Neurology Neuroscience

·May 8, 2025·4 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

New research shows that HIV drugs called NRTIs may significantly reduce the risk of developing Alzheimer’s disease. Analyzing two large health databases, scientists found that patients on NRTIs had a 6% to 13% annual decrease in Alzheimer’s risk.

Featured Neuroscience

·May 7, 2025·7 min read

Western Diet Blocks Gut Microbiome Recovery After Antibiotics

New research shows that a Western-style diet rich in processed foods disrupts the gut microbiome’s ability to recover after antibiotic treatment. In mice, this diet prevented the regrowth of a healthy, diverse microbiome, leaving them more vulnerable to infections like Salmonella.

This shows a person sitting and mushrooms.

Featured Neurology Neuroscience

·April 30, 2025·6 min read

Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

A new pilot study reveals that psilocybin—the compound found in psychedelic mushrooms—may significantly improve mood, cognition, and motor function in people with Parkinson’s disease. The compound was well tolerated, with only mild side effects, and benefits persisted for weeks after dosing. While the study was primarily designed to test safety, researchers observed meaningful and lasting improvements in multiple symptoms.

Featured Neuroscience

·April 26, 2025·4 min read

Early Antibiotic Use Linked to Higher Childhood Obesity Risk

A new study reveals that taking antibiotics within the first two years of life is associated with higher childhood body mass index (BMI) and increased obesity risk. Researchers found that early antibiotic exposure raised BMI, and increased the risk of being overweight by 9% and obese by 20%.

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neuropharmacology

New Alzheimer’s Drug Boosts Brain Protection, Restores Memory

Next-Gen Painkiller Blocks Pain Without the High

Vitamin B1 Derivative Sparks Dopamine, Boosts Wakefulness

Tylenol Targets Pain Through Unexpected Endocannabinoid Pathway

Gabapentin Linked to Longer Survival in Glioblastoma Brain Cancer

Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Trial

CAR-T Brain Fog Mirrors Chemo and COVID

Brain Wave Phase Locking May Be Key to Unconsciousness

HIV Drugs Linked to Lower Alzheimer’s Risk

Western Diet Blocks Gut Microbiome Recovery After Antibiotics

Psilocybin Shows Promise for Parkinson’s Mood and Motor Symptoms

Early Antibiotic Use Linked to Higher Childhood Obesity Risk

Whiskers That Whisper: Mice Use Sound to Sense Their World

New Tool Tracks Individual Brain Cells in Mice for Up to 99 Days

Boosting Ketamine’s Antidepressant Effects to Last Two Months

Smart Floss Measures Stress Hormone for Easy, Real-Time Monitoring

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