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neuropharmacology

Brain Cancer Featured Neurology Neuroscience

·December 4, 2025·9 min read

Fungal Molecule Shows Promise Against Brain Cancer

For the first time, chemists have fully synthesized verticillin A, a notoriously complex fungal molecule with striking anticancer potential. The molecule’s fragile structure required a complete rethinking of its synthetic sequence, enabling researchers to not only recreate it but design more stable and potent derivatives.

This shows a brain and three supplement pills

Autism Featured Neuroscience

·December 2, 2025·8 min read

Supplement Mix Reverses Autism Traits

Researchers have made a major advance, discovering that a low-dose mixture of zinc, serine, and branch-chain amino acids (BCAAs) can successfully alleviate behavioral symptoms in three different mouse models of autism. This breakthrough lies in the synergy of the three common nutrients, which work together to restore normal neural communication and reduce hyperactivity in the brain's emotional center.

This shows an older woman getting a vaccine.

Neuroscience

·December 2, 2025·12 min read

Shingles Vaccine Linked to 20% Lower Dementia Risk

A large population analysis found that older adults who received the shingles vaccine were significantly less likely to develop dementia over the following seven years. The study exploited a rare age-based rollout policy that closely mimicked a randomized trial, allowing researchers to isolate the vaccine’s true effect.

This shows the HIV virus and blood cells.

Featured Neurology Neuroscience

·December 1, 2025·7 min read

Scientists Achieve Sustained HIV Control Without Lifelong Drugs

Scientists tested a multi-step immune-based therapy designed to retrain the body to control HIV without continuous antiviral treatment. After stopping standard HIV drugs, seven out of ten participants maintained low viral levels for extended periods, and one showed no viral rebound at all.

This shows the outline of a head in psychedelic colors.

Featured Neuroscience Psychology

·November 24, 2025·4 min read

Psychedelic ‘Ego Death’ Tied to a Collapse in Alpha Brain Waves

A new study using DMT as a scientific tool reveals how psychedelics alter the brain’s alpha-wave dynamics and weaken our sense of self. The researchers found that DMT pushes the brain away from its usual “critical” balance between chaos and order, a state believed to be essential for coherent self-awareness over time.

This shows a head, a brain, and supplement pills.

Featured Neurology Neuroscience

·November 21, 2025·6 min read

Supplement Shows Promise in Blocking Amyloid in Alzheimer’s

A new study shows that oral arginine, a naturally occurring amino acid, can significantly suppress amyloid-β aggregation in Alzheimer’s disease models. Researchers found that arginine not only prevented Aβ42 from clumping but also reduced plaques and inflammation in mouse and fruit fly models carrying Alzheimer’s-related mutations.

Featured Neuroscience

·November 17, 2025·6 min read

Animal-Free Brain Tissue Breakthrough Could Transform Drug Testing

Researchers have created functional brain-like tissue without relying on any animal-derived materials, marking a major step toward more ethical and reproducible neurological research. By transforming a chemically inert polymer (PEG) into a porous, maze-like scaffold, scientists enabled donor brain cells to organize into active neural networks.

Featured Neuroscience

·November 17, 2025·9 min read

How Mounjaro Alters Craving Circuits in the Brain

A rare intracranial brain-recording study revealed that tirzepatide, a GLP-1 and GIP receptor agonist, temporarily silences craving-related neural activity in a key reward circuit of the brain. Using implanted electrodes in a patient with treatment-resistant obesity and loss of control eating, researchers observed that the drug initially shut down signaling in the nucleus accumbens.

Featured Neurology Neuroscience

·November 12, 2025·5 min read

Alzheimer’s Drug Reduces Amyloid but Fails to Restore Brain Waste Flow

Researchers found that lecanemab, the Alzheimer’s drug designed to clear amyloid-β plaques, does not improve the brain’s waste clearance system in the short term. In a three-month study using MRI-based DTI-ALPS imaging, scientists observed no measurable recovery in glymphatic function after treatment.

This shows a man holding a wine glass against a psychedelic backdrop.

Featured Neuroscience

·November 10, 2025·4 min read

Psychedelics Calm Stress Circuits to Reduce Alcohol Drinking

New research shows that psilocin, the active metabolite of the psychedelic psilocybin, may reduce alcohol consumption by calming stress-sensitive neurons in the central amygdala. In female mice exposed to long-term alcohol use, psilocin dampened the hyperactivity of these neurons, temporarily reducing drinking.

Featured Neurology Neuroscience Pain

·November 7, 2025·5 min read

Nano Tech Helps CBD Quiet Pain at the Source

A new study shows that CBD delivered through a nano-micelle system can cross the blood–brain barrier and produce rapid neuropathic pain relief. The formulation, called CBD-IN, helped mice within 30 minutes and avoided the motor and cognitive side effects often seen with conventional pain drugs.

Brain Cancer Featured Neurology Neuroscience

·October 29, 2025·6 min read

How Chemotherapy Triggers Nerve Damage, and How to Stop It

A new study reveals that chemotherapy-induced nerve pain arises from a stress response in immune cells that triggers inflammation and neurotoxicity. Researchers found that activating a cellular stress sensor called IRE1α causes nerve damage and pain during chemotherapy, but blocking it prevents both in mice.