Study reveals how the brain's opioid system is linked to mood changes associated with depression and anxiety. Neuroimaging revealed, in those with depression, there is a decreased number of opioid receptors in specific areas of the brain.
Age, sex, and gender influence the organization of the brain's opioid system. Findings shed light on why there are significant differences between the opioid system on an individual level, and why some are more prone to developing opioid-linked pathologies than others.
Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia.
A PET neuroimaging study reveals high intensity impact training significantly increases endorphin release in brain areas associated with controlling emotion and pain.
Researchers have identified a subset of neurons which mediate tactile allodynia, a touch evoked pain condition that is resistant to conventional pain medications.