HDAC5, the "epigenetics" enzyme, plays a key role in limiting opioid-associated memories and drug-seeking behaviors following abstinence from drugs in rats. The findings provide a new avenue for the treatment of opioid addiction.
Inducing massive inflammation resulted in an overexpression of Trpv4. The overexpression led to neural hyperexcitability that resulted in social avoidance behaviors associated with ASD in mouse models.
Researchers have identified different neuron types and provided a new list of genes associated with schizophrenia. The findings could pave the way for developing new targeted therapies to treat the condition.