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·April 25, 2020·3 min read

Novel Compounds Designed To Inhibit SARS-CoV-2 Main Protease

Researchers have developed two new compounds that are able to inhibit SARS-CoV-2 main protease. The study reports one of the compounds is a strong drug candidate for further investigative trials in the treatment of coronavirus.

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·April 24, 2020·3 min read

Purified botanical CBD reduces early death in Dravet syndrome

Using purified botanical cannabidiol (CBD) to treat mouse models of Davet syndrome improved mortality and reduced behavioral symptoms associated with the condition.

Featured Genetics Neuroscience

·April 24, 2020·3 min read

Asthma drug in clinical trial to treat severe COVID-19 patients

A new clinical trial is underway to test ibudilast, an asthma drug approved in Japan, for the treatment of severe COVID-19. Ibudilast is a MIF inhibitor. MIF is a gene that regulates immune response and is a driver of inflammation which results in the cytokine storm associated with coronavirus.

Featured Neuroscience

·April 23, 2020·5 min read

Key nose cells identified as likely COVID-19 virus entry points

The receptor protein ACE2 and the TMPRSS2 protease that can activate SARS-CoV-2 entry are expressed in cells on the inner lining of the nose. Mucus producing goblet cells and ciliated cells in the nose have the highest levels of both proteins, making them the most likely initial infection route for coronavirus. Additional key entry points were found in the cells of the eye's cornea and the intestines. This suggests other points of infection could be via the tear ducts and through fecal-oral transmission.

Featured Neuroscience

·April 20, 2020·3 min read

Early antibody testing results reveal more COVID-19 infections than confirmed cases

The first round of antibody testing in L.A country reveals approximately 4.1% of the adult population has COVID-19 antibodies. Adjusting for margin of error, between 2.8% to 5.6% of the adult population has antibodies to the virus. This means between 221,000 and 442,000 adults in the Los Angeles area have been infected with coronavirus. The estimate is up to 55 times higher than confirmed cases reported for the area.

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·April 20, 2020·7 min read

Live virus used to identify 30 existing drugs that could successfully treat COVID-19

27 existing drugs which are currently not under evaluation for COVID-19 are effective at halting the replication of SARS-CoV-2. Four of the drugs, apilimod, MLN-3897, VBY-825, and ONO 5334, which have previously been tested for the treatment of a range of diseases from rheumatoid arthritis to cancer, appear to be the best candidates for coronavirus treatment.

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·April 16, 2020·3 min read

Impaired Blood Clotting May Explain Higher COVID-19 Risk

Higher levels of plasmin, an enzyme involved in blood clotting prevention, enhances the virulence and infectivity of SARS-CoV-2 by cleaving its spike proteins. Enhanced levels of plasmin are common in a range of diseases, including diabetes and heart disease. The findings shed light on why those with hypertension and diabetes are at increased risk of complications following coronavirus infection.

Featured Genetics Neuroscience

·April 16, 2020·3 min read

Proteins may halt the severe cytokine storms seen in COVID-19 patients

Researchers have designed antibody-like receptor proteins that can bind to cytokines, possibly reducing the effects of the COVID-19 associated cytokine storm.

Featured Neuroscience Open Neuroscience Articles

·April 16, 2020·3 min read

Development of antibody research may help prevent sepsis induced by COVID-19

Researchers have developed a novel antibody strategy to prevent the association between a harmless protein and a disease mediator that could lead to sepsis, and ultimately death. The findings could help to prevent sepsis induced by COVID-19 infections.

This shows a woman in a facemask holing a flower

Featured Neuroscience Open Neuroscience Articles

·April 16, 2020·3 min read

Study identifies 275 ways to reduce spread of coronavirus following lockdown

Study identifies 275 ways to help reduce the transmission of COVID-19 when countries eventually attempt to reduce social distancing pract

Featured Neuroscience Open Neuroscience Articles

·April 15, 2020·4 min read

COVID-19: Exercise may protect against deadly complication

Regular exercise may help prevent or reduce the severity of ARDS for those with coronavirus. A single session of exercise increases the production of a critical antioxidant, called EcSOD, helping to reduce the effects of COVID-19 infection.

Featured Neuroscience

·April 14, 2020·4 min read

Targeting cell’s own machinery in fight against COVID-19

Coronaviruses rely on the TOP3B enzyme as a host factor, researchers report. Using artificial intelligence and molecular modeling, researchers were able to identify drug candidates that could serve as TOP3B inhibitors. Studies are now underway to test the drug candidates against living cell cultures and viruses, including COVID-19.