Findings about the distribution of condensates in Rett syndrome shed light on how cells compartmentalize chromosomes and provide new insights into potential paths of therapies for the neurodevelopmental disorder.
Abnormal activation of parvalbumin neurons in the young mouse auditory cortex manifests as a result of maternal neglect.
Isoguavacine, an old experimental compound which exclusively targets peripheral neurons, mitigates abnormal touch sensitivity in mouse models of ASD. The compound also improved body mass, reduces anxiety, and in one genetic subset of mice, prevented the development of brain abnormalities that arise from altered touch response.
A new study reports a protein associated with Rett syndrome is also among a group of three proteins that affect the function of a gene previously linked to OCD.
Researchers have identified an important signaling pathway that, when corrected, appears to improve symptoms of Rett syndrome in mice.