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Mass Eye and Ear

Featured Genetics Neuroscience Visual Neuroscience

·May 6, 2024·7 min read

CRISPR Trial Provides Hope for Inherited Blindness

A recent clinical trial, BRILLIANCE demonstrated the safety and efficacy of CRISPR gene editing in treating inherited blindness caused by mutations in the CEP290 gene. The study involved 14 participants who received a single injection of the CRISPR/Cas9-based medicine, EDIT-101, which showed measurable improvements in 11 participants' vision.

Auditory Neuroscience Featured Neuroscience

·November 30, 2023·3 min read

Tinnitus Linked to Auditory Nerve Loss

A new study reveals that tinnitus, a common auditory issue characterized by ringing in the ears, is associated with undetected auditory nerve loss. This finding challenges the traditional understanding that tinnitus is solely a result of brain maladaptation to hearing loss.

Auditory Neuroscience Featured Genetics Neuroscience

·May 27, 2023·3 min read

Gene Therapy Reverses Age-Related Hearing Loss

Researchers successfully demonstrated the efficacy of adeno-associated virus (AAV) vectors in reversing genetic hearing loss in aged animal models. The scientists developed a mature mouse model with a mutation similar to the human TMPRSS3 gene defect, which typically results in progressive hearing loss.

Featured Genetics Open Neuroscience Articles

·July 26, 2017·4 min read

Genome Editing with CRISPR-Cas9 Prevents Angiogenesis of the Retina

CRISPR gene editing has allowed researchers to prevent angiogenesis of the retina occurring in mice. Researchers say the new technology could help prevent vision loss in those with retinal diseases.