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ketones

·April 24, 2025·5 min read

When the Brain Lacks Fuel, Exercise Still Protects Memory

New research shows that exercise may protect brain function even when the body can’t produce ketones, a vital energy source for cognition. When liver function is impaired and ketone levels drop, memory and learning typically suffer—but physical activity can still counteract those effects.

Brain Cancer Featured Neuroscience

·December 7, 2024·5 min read

Ketogenic Diet Enhances CAR-T Cancer Therapy

Researchers have found that a ketogenic diet boosts CAR T cell therapy effectiveness by enhancing tumor control and survival in mice with lymphoma. The key is beta-hydroxybutyrate (BHB), a metabolite produced during ketosis, which CAR T cells prefer as an energy source over glucose. Laboratory models showed that BHB supplementation led to complete cancer remission in most mice and enhanced CAR T cell expansion.

Featured Neuroscience

·December 2, 2024·6 min read

Ketone Bodies Clear Damaged Proteins in the Brain

Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy. Researchers discovered that the ketone body β-hydroxybutyrate alters the solubility of misfolded proteins, facilitating their removal and reducing pathological aggregation.

Featured Neurology Neuroscience

·May 31, 2024·3 min read

Ketones May Help Reverse Cognitive Decline

As we age, our brain naturally becomes more insulin resistant, disrupting neuron communication and leading to cognitive decline and neurodegeneration. Researchers studied how acute insulin resistance impacts neuronal function before symptoms of chronic conditions like Alzheimer's manifest.

Featured Neuroscience Psychology

·April 27, 2020·2 min read

High-fat diet consequences include mental fatigue

Rats fed on a high-fat diet were more mentally exhausted following a novel object recognition test than those fed a healthier diet. Findings suggest high-fat diets not only contribute to obesity, but they can also have an impact on mental fatigue and cognitive abilities.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 5, 2020·6 min read

Low carb diet may prevent and reverse age-related effects within the brain

Researchers report a low carb-based diet may help to prevent or reverse signs of early brain aging in middle-aged people.

This shows high protein food and a calender

Featured Neuroscience

·February 2, 2020·4 min read

Keto diet works best in small doses

In the short term, a ketogenic diet can help improve health as well as assist in weight loss. However, the negative effects of the keto diet start to appear after one week. Mice who were fed a ketogenic-style diet for more than seven days consumed more fat than they could burn, and had an increased risk of developing diabetes and obesity.

Featured Neurology Neuroscience Open Neuroscience Articles

·December 28, 2019·5 min read

Ketogenic diet reduces aggression after concussion

Male fruit flies fed a ketone supplemented diet expressed reduced levels of aggression following concussion than those who were not exposed to the dietary intervention.

Featured Neurology Neuroscience

·December 9, 2019·2 min read

Eating more ketones may fight against Alzheimer’s disease

Increasing SIRT3 levels with a ketone rich diet may help protect GABAergic interneurons and delay the onset of Alzheimer's disease.

Featured Neurology Neuroscience

·June 27, 2019·7 min read

Low-carb ‘keto’ or ‘Atkins-style’ diet may modestly improve cognition in older adults

A small scale pilot study reveals adults with mild cognitive impairment may have improved brain function and memory when they switch to a high-fat, low-carb diet.

Featured Neurology Open Neuroscience Articles

·September 22, 2017·5 min read

How Ketogenic Diets Curb Inflammation

The neurological benefits experienced by those with epilepsy who follow ketogenic diets may be a result of the low carb diet lowering brain inflammation, researchers report.