In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
Researchers have detected biomarkers for the common fungicide azoxystrobin (AZ) in the urine of pregnant women and children between the ages of 40-84 months. In mouse models, AZ entered the brains of mice in-utero and killed some embryonic cortical neurons.
Transplanting fecal microbiota from young mice to older mice reversed hallmark signs of aging in the gut, brains, and eyes. Transplanting the fecal microbiota from old to young mice had the reverse effect, inducing inflammation in the brain and depleting a key protein associated with healthy vision.
Administering a lipid that mediates inflammation reduced chronic inflammation associated with multiple sclerosis in mouse models. Researchers found these mediator lipids are reduced in humans with multiple sclerosis.
From helping to improve attention and staving off cognitive decline, to improving immune system function, researchers explore the many health benefits tea has to offer.
New findings reveal phagocytes do not fully mature until after birth, contradicting previous assumptions that they mature during embryonic development.
The activation of a neural circuit comprising of the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the first hours following sepsis infection induced anxiety behaviors in mice two weeks after the infection cleared. The behaviors mimicked the PTSD symptoms patients experience following sepsis infection.
Daily vaping of pod-based e-cigarettes alters inflammatory states across multiple organs, including the brain. The effects vary depending upon the vape flavors and influence how the body responds to infections. Mint vapes, for example, leave people more sensitive to the effects of bacterial pneumonia than mango flavoring.
Lower gray matter volume in the brain is indicative of a higher risk of developing mental health disorders including depression and psychosis. However, those with slightly greater gray matter volume were more likely to recover from their disorders. Researchers believe reduced gray matter volume may be linked to higher levels of inflammation, reduced concentration, and other cognitive impairments associated with disorders like schizophrenia.