Pain-sensing neurons in the put secrete substance P, a molecule that protects against gut inflammation and tissue damage by boosting specific microbes in the gut. In people with inflammatory bowel disease, the pain-sensing neurons are diminished and there are significant disruptions in pain-signaling genes.
DKT, a Japanese herbal remedy containing ginger, pepper, ginseng, and maltose, reduced symptoms of colitis in mice, a new study reports.
Patients diagnosed with inflammatory bowel disease are 9 times more likely to develop depression than those without IBD. Those with depression are twice as likely to develop inflammatory bowel disease, a new study reports.
Mice with cytokine IL-23 dysregulation who consumed foods containing the artificial colorants FD&C Red 40 and Yellow developed colitis, a new study reports.
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems.
Children with inflammatory bowel disease (IBD) are at increased risk of being diagnosed with a mental health problem. The risk of being diagnosed with a psychiatric condition is 1.6 times higher for those with IBD than the general population. IBD is associated with an increased risk of eating disorders, anxiety, depression, personality disorders, and ASD diagnosis. Researchers report there is also an increased risk of suicidal thoughts when the child reaches adulthood. The risk of being diagnosed with a psychiatric disorder was highest during the first year of IBD diagnosis, especially in children diagnosed with the condition before the age of 6.
A link between disease activity in those with inflammatory bowel disease and less positive biases in emotional regulation could explain a higher risk of depression in those with IBD.
Diagnosis of inflammatory bowel diseases like Crohn's disease and ulcerative colitis during adulthood has been linked to a 50% higher mortality rate and shorter life expectancy in those over 50. The increased risk of death remained after the introduction of therapies aimed at treating the conditions but decreased over time.