Xanthine, a purine metabolite found in caffeinated products such as coffee and tea, and in chocolate, appears to play a role in TH17 cell differentiation in the gut. The findings may lead to a better understanding of gut health and shed new light on the development of inflammatory disorders such as IBD.
Better education has a strong genetic correlation and protective causal association against several disorders that affect the gut, a new study reports.
Adult exposure to antibiotics appears to be linked to an increased risk of developing an inflammatory bowel disorder, including Crohn's disease and ulcerative colitis. The risk appears to be cumulative, greatest around two years after use, and for antibiotics that target gut infections.
Pain-sensing neurons in the put secrete substance P, a molecule that protects against gut inflammation and tissue damage by boosting specific microbes in the gut. In people with inflammatory bowel disease, the pain-sensing neurons are diminished and there are significant disruptions in pain-signaling genes.
DKT, a Japanese herbal remedy containing ginger, pepper, ginseng, and maltose, reduced symptoms of colitis in mice, a new study reports.
Patients diagnosed with inflammatory bowel disease are 9 times more likely to develop depression than those without IBD. Those with depression are twice as likely to develop inflammatory bowel disease, a new study reports.
Mice with cytokine IL-23 dysregulation who consumed foods containing the artificial colorants FD&C Red 40 and Yellow developed colitis, a new study reports.
Two studies reveal the role bile acids play in immunity and inflammation.
Short term increases in sugar consumption raise the susceptibility to colitis and worsen symptoms of inflammatory bowel disease in mouse models.
Study provides new insights into how the immune system and inflammation play a role in the development and progression of Parkinson's disease.
Mice bred to be germ-free, and those treated with antibiotics showed a significant reduction in the ability to learn that a threatening danger was no longer present. Sequencing the RNA of microglia in the brains of the animals reveals altered gene expression in the immune cells, which play a role in remodeling how neurons connect during the learning process. Restoring the gut microbiota reverse the learning problems.
Children with inflammatory bowel disease (IBD) are at increased risk of being diagnosed with a mental health problem. The risk of being diagnosed with a psychiatric condition is 1.6 times higher for those with IBD than the general population. IBD is associated with an increased risk of eating disorders, anxiety, depression, personality disorders, and ASD diagnosis. Researchers report there is also an increased risk of suicidal thoughts when the child reaches adulthood. The risk of being diagnosed with a psychiatric disorder was highest during the first year of IBD diagnosis, especially in children diagnosed with the condition before the age of 6.