Huntington’s disease

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Huntington’s disease

Featured Neurology Open Neuroscience Articles

·August 6, 2020·4 min read

Gut Bacteria in People With Huntington’s Disease May Be a Potential Drug Target

Study provides evidence of gut dysbiosis associated with Huntington's disease. Some of the gut measures were associated with disease symptoms such as movement and cognitive impairment. The findings could provide a new avenue of treatment for the neurodegenerative disease. Read More

Featured Genetics Neurology

·July 22, 2020·6 min read

Neural Vulnerability in Huntington’s Disease Tied to Release of Mitochondrial RNA

In both human cell and mouse models of Huntington's disease, RNA from mitochondria was misplaced within spiny projection neurons. The stray RNAs, which looked different to cells than RNA derived from the cell nucleus, trigger an immune reaction that can lead to striatal cell type vulnerability. Read More

Featured Genetics Neurology Open Neuroscience Articles

·July 18, 2020·5 min read

Study Reveals Intricate Details About Huntington’s Disease Protein

A mutated form of the huntingtin protein disrupts the normal movement of vesicles holding HT and Rab4. This leads to defects in synapses, resulting in movement abnormalities and lifespan decreases in fruit fly larvae. Findings suggest Rab4 could be a novel therapeutic target for the early intervention of Huntington's disease, before the neuronal loss and behavioral deficits associated with the neurodegenerative disorder. Read More

Featured Genetics Neurology Neuroscience

·April 15, 2020·4 min read

When damaged, the adult brain repairs itself by going back to the beginning

Mouse models of corticospinal injuries reveal adult neurons begin a natural regeneration process by reverting back to an embryonic state. The regeneration is sustained with the help of a gene more commonly associated with Huntington's disease. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·February 20, 2020·4 min read

Language disorders as indicators of the diagnosis and progression of Huntington’s disease

Study reports it may be possible to detect the onset and progression of Huntington's disease through linguistic changes in patients. Linguistic impairments often begin before the onset of other Huntington's symptoms. Read More

Artificial Intelligence Deep Learning Featured Genetics Machine Learning Neurology Neuroscience Neurotech

·January 28, 2020·3 min read

AI analyzed blood test can predict the progression of neurodegenerative disease

Combining artificial intelligence technology and blood samples, researchers were able to predict and explain the progression of Alzheimer's and Huntington's disease. The new algorithm was able to detect alterations in gene expression over decades from patients' blood samples. Read More

This shows the BBB created on the organ-chip

Featured Neurology Neuroscience

·June 6, 2019·4 min read

Scientists recreate blood-brain barrier defect outside the body

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips. Read More

Featured Genetics Neurology Neuroscience

·May 13, 2019·3 min read

How mutations lead to neurodegenerative disease

Genetic mutations which lead to abnormal RNA in regions of repeat DNA sequences set off anti-viral like inflammatory responses. This leads to apoptosis and ultimately trigger the onset of neurodegenerative diseases. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·April 2, 2019·4 min read

Circadian clock plays unexpected role in neurodegenerative diseases

Disrupted sleep patterns may help to protect neurons in the brain in Huntington's disease. Read More

Featured Genetics Neurology Open Neuroscience Articles

·January 13, 2019·3 min read

Speeding Up Genetic Diagnosis of Huntington’s Disease

Researchers have developed a method to determine the length of mutated genes associated with Huntington's disease quickly and easily. Read More

Featured Neurology Neuroscience

·October 19, 2018·5 min read

Regulating Microglial Activity May Reduce Inflammation in Neurodegenerative Diseases

Researchers report activating microglia may help reduce the imbalance between neuroprotection and neurotoxicity for neurodegenerative diseases. Read More

Featured Genetics Neurology

·September 3, 2018·3 min read

Huntington’s Disease Starts in Childhood

Researchers say the Huntingtin gene affects brain development from an early age, even though most patients do not develop Huntington's disease until later life. Read More

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