FeaturedNeurologyNeuroscience·January 20, 2023·6 min readHow Huntington’s Disease Affects Different NeuronsResearchers have identified how two different populations of neurons in the striatum are affected differently in Huntington's disease. The neurodegeneration of one of these populations leads to motor defects while damage to the other population located in striosomes may account for mood disorders associated with the early stages of Huntington's.Read More
FeaturedGeneticsNeurologyNeuroscience·December 12, 2022·4 min readCRISPR Technology Improves Huntington’s Disease Symptoms in ModelsUsing CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.Read More
FeaturedNeurologyNeuroscience·October 28, 2022·6 min readCellular Housekeeping Process Implicated in Huntington’s DiseaseStudy reveals how aging impairs autophagy and how enhancing autophagy can prevent cells from dying in Huntington's disease.Read More
FeaturedGeneticsNeurologyNeuroscience·September 27, 2022·4 min readStudy Probes Huntington’s Disease Protein’s Function in Injured NeuronsThe Huntington's disease protein huntingtin may have a role external to the neurodegenerative disease. Researchers say Huntingtin is involved in neural injury and regeneration.Read More
FeaturedNeurologyNeuroscience·September 19, 2022·3 min readDiscovery of the Causes of Brain Dysfunction in Patients With Huntington’s DiseaseResearchers discovered decreased function in a protein critical for synaptic function in those with Huntington's disease.Read More
FeaturedGeneticsNeurologyNeuroscience·August 17, 2022·3 min readReprogramming Human Skin Cells Into Aged Neurons to Study Neurodegenerative DisordersConverting skin cell samples into neurons helps researchers gain a better understanding of the mechanisms of Huntington's disease.Read More
FeaturedNeurologyNeuroscience·February 15, 2022·7 min readA New Atlas of Cells That Carry Blood to the BrainResearchers have created a comprehensive atlas of cell types in the brain's cerebrovascular system.Read More
FeaturedGeneticsNeurologyNeuroscience·November 29, 2021·5 min readWhy Some People Experience Early Onset Neurodegenerative DiseasesA new study sheds light on the genetic causes of a range of neurodegenerative disorders, including ALS, Parkinson's disease, and Huntington's disease, and determines factors that impact the age of onset as well as disease severity.Read More
FeaturedNeurologyNeuroscience·October 5, 2021·4 min readStudy Detects Origins of Huntington’s Disease in Two-Week-Old Human EmbryosSynthesizing a human embryo from stem cells and using gene editing to insert the Huntingtin gene, researchers found the mutation affected the size of germ layers compared to the control embryos. Findings suggest Huntington's disease may be a neurodevelopmental disorder that presents as a neurodegenerative disease laterRead More
FeaturedNeurologyNeuroscience·July 15, 2021·4 min readAutophagy May Be the Key to Finding Treatments for Early Huntington’s DiseaseDisruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.Read More
FeaturedGeneticsNeurologyOpen Neuroscience Articles·March 6, 2021·4 min readHuntington’s Disease Driven by Slowed Protein-Building Machinery in CellsThe mutated huntingtin protein slows ribosome movement and decreases protein synthesis.Read More
FeaturedGeneticsNeurologyNeuroscience·January 7, 2021·6 min readEffects of Huntington’s Disease Mutation May Begin in ChildhoodA new study adds to the growing body of evidence that the origin of Huntington's disease is rooted in childhood. Researchers say the HTT gene mutation affects both brain and body growth during development, and the increased susceptibility of brain cell death begins early in life.Read More
