Huntington’s disease

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Huntington’s disease

·October 5, 2021·4 min read

Study Detects Origins of Huntington’s Disease in Two-Week-Old Human Embryos

Synthesizing a human embryo from stem cells and using gene editing to insert the Huntingtin gene, researchers found the mutation affected the size of germ layers compared to the control embryos. Findings suggest Huntington's disease may be a neurodevelopmental disorder that presents as a neurodegenerative disease later

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·July 15, 2021·4 min read

Autophagy May Be the Key to Finding Treatments for Early Huntington’s Disease

Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington's disease.

This shows neurons. The caption best describes the image

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·March 6, 2021·4 min read

Huntington’s Disease Driven by Slowed Protein-Building Machinery in Cells

The mutated huntingtin protein slows ribosome movement and decreases protein synthesis.

This is a graphic abstract from the study

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·January 7, 2021·6 min read

Effects of Huntington’s Disease Mutation May Begin in Childhood

A new study adds to the growing body of evidence that the origin of Huntington's disease is rooted in childhood. Researchers say the HTT gene mutation affects both brain and body growth during development, and the increased susceptibility of brain cell death begins early in life.

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·December 6, 2020·4 min read

Study Links Cases of ALS and FTD to a Huntington’s Disease-Associated Mutation

Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin.

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·August 6, 2020·4 min read

Gut Bacteria in People With Huntington’s Disease May Be a Potential Drug Target

Study provides evidence of gut dysbiosis associated with Huntington's disease. Some of the gut measures were associated with disease symptoms such as movement and cognitive impairment. The findings could provide a new avenue of treatment for the neurodegenerative disease.

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·July 22, 2020·6 min read

Neural Vulnerability in Huntington’s Disease Tied to Release of Mitochondrial RNA

In both human cell and mouse models of Huntington's disease, RNA from mitochondria was misplaced within spiny projection neurons. The stray RNAs, which looked different to cells than RNA derived from the cell nucleus, trigger an immune reaction that can lead to striatal cell type vulnerability.

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·July 18, 2020·5 min read

Study Reveals Intricate Details About Huntington’s Disease Protein

A mutated form of the huntingtin protein disrupts the normal movement of vesicles holding HT and Rab4. This leads to defects in synapses, resulting in movement abnormalities and lifespan decreases in fruit fly larvae. Findings suggest Rab4 could be a novel therapeutic target for the early intervention of Huntington's disease, before the neuronal loss and behavioral deficits associated with the neurodegenerative disorder.

Featured Genetics Neurology Neuroscience

·April 15, 2020·4 min read

When damaged, the adult brain repairs itself by going back to the beginning

Mouse models of corticospinal injuries reveal adult neurons begin a natural regeneration process by reverting back to an embryonic state. The regeneration is sustained with the help of a gene more commonly associated with Huntington's disease.

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·February 20, 2020·4 min read

Language disorders as indicators of the diagnosis and progression of Huntington’s disease

Study reports it may be possible to detect the onset and progression of Huntington's disease through linguistic changes in patients. Linguistic impairments often begin before the onset of other Huntington's symptoms.

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·January 28, 2020·3 min read

AI analyzed blood test can predict the progression of neurodegenerative disease

Combining artificial intelligence technology and blood samples, researchers were able to predict and explain the progression of Alzheimer's and Huntington's disease. The new algorithm was able to detect alterations in gene expression over decades from patients' blood samples.

This shows the BBB created on the organ-chip

Featured Neurology Neuroscience

·June 6, 2019·4 min read

Scientists recreate blood-brain barrier defect outside the body

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips.

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