A large, genome-wide study in children reveals genetic variants associated with differing levels of antibodies produced as a result of three common childhood vaccinations. Researchers identified two genetic loci associated with the persistence of vaccine-induced immunity following early life vaccinations. The results may help clinicians tailor personalized vaccine schedules to maximize the effectiveness of immunizations.
Researchers have identified a new mechanism of a risk gene for multiple sclerosis that triggers the disease via epigentic regulation. The study reports a protective genetic variant can reduce the risk of multiple sclerosis through the same mechanism.
Researchers identify regions of genes linked to Behçet’s disease, a poorly understood condition that causes painful and serious symptoms, including ulcers and brain inflammation. The study identified novel gene variants in the inflammatory disorder and uncovered data that could apply to studies of other diseases.