Study reports in the short term, astrocytes regulate caloric intake by controlling the signaling pathway between the gut and brain. Eating high-fat or high-calorie diets disrupts this pathway.
High-fat diets promote early inflammatory responses in the brain via an immune pathway associated with diabetes and neurodegenerative diseases. The findings suggest a link between metabolic dysfunction and cognitive impairment.
High-fat diets induce hyperalgesic priming, a neurological change that represents the transition from acute to chronic pain, and allodynia or pain resulting from stimuli that do not normally provoke pain.
Mice fed a high-fat diet for 30 weeks were considerably more likely to develop diabetes, face cognitive impairments, and develop depression and anxiety. The mice with diet-induced cognitive impairment were also more likely to gain weight excessively due to poor metabolism caused by the brain changes.
Rats fed on a high-fat diet were more mentally exhausted following a novel object recognition test than those fed a healthier diet. Findings suggest high-fat diets not only contribute to obesity, but they can also have an impact on mental fatigue and cognitive abilities.
Combining medications used to treat neurological disorders, such as epilepsy and migraines, with blood pressure medications reversed some aspects of breast cancer in mice at high risk of developing the disease due to the high-fat diets fed to their mothers during pregnancy.
Female mice exposed to a high-fat diet have limited hippocampal neurogenesis. The findings may explain why women are at higher risk of developing dementia than men.
When pregnant women consume diets high in polyunsaturated omega-6 fatty acids, an excess of endocannabinoids is produced which overloads the fetus, and impairs healthy brain development.
High-fat diets are not only bad for your waistline, they are also bad for your brain health. A new study reveals high-fat diets contribute to hypothalamic inflammation which occurs long before symptoms of obesity arise.
Maternal exposure to a high-fat diet during pregnancy and lactation can have a lasting, detrimental effect on the cognitive ability and behaviors of their offspring.