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          gene editing

          This shows an AI representation of mitochondria.
          FeaturedGeneticsNeuroscience
          ·November 22, 2024·4 min read

          Mitochondrial Gene Editing Reveals Links to Memory

          Researchers used mitochondrial gene editing to model genetic disorders in mice, revealing profound impacts on brain function, metabolism, and thermoregulation. They employed a specialized DNA editing tool to induce mutations in the ND5 mitochondrial gene, disrupting energy production and causing learning deficits, hippocampal atrophy, and obesity.
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          This shows a diagram of HACE gene editing.
          FeaturedGeneticsNeuroscience
          ·November 17, 2024·6 min read

          New Gene-Editing Tool Targets Mutations with Unmatched Precision

          A breakthrough tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to create precise genetic mutations in specific genes without affecting the rest of the genome. By combining helicase enzymes with CRISPR technology, HACE introduces mutations into targeted DNA sequences, advancing our ability to study gene functions and disease mechanisms. The tool has already identified drug resistance mutations in cancer-related genes and splicing defects in blood cancers, showcasing its potential for therapeutic discovery.
          Read More
          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·May 20, 2024·6 min read

          CRISPR Screen Unlocks Brain’s “Black Box”

          Scientists have developed a groundbreaking CRISPR screening method called in vivo Perturb-seq. This innovative technique allows for rapid and scalable analysis of how genetic changes affect individual brain cells, offering new insights into the cellular drivers of neurological diseases. By understanding how specific cell types respond to genetic perturbations, researchers can identify potential therapeutic targets and develop more effective treatments.
          Read More
          This shows DNA.
          FeaturedGeneticsNeuroscience
          ·May 9, 2024·6 min read

          New Tech Unlocks Secrets of Gene Regulation and Epigenetics

          Researchers developed an innovative epigenome editing platform that enables precise programming of epigenetic modifications across the genome. This technology uses CRISPR to target and modify chromatin, facilitating detailed studies on how these changes affect gene expression.
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          This shows an eye.
          FeaturedGeneticsNeuroscienceVisual Neuroscience
          ·May 6, 2024·7 min read

          CRISPR Trial Provides Hope for Inherited Blindness

          A recent clinical trial, BRILLIANCE demonstrated the safety and efficacy of CRISPR gene editing in treating inherited blindness caused by mutations in the CEP290 gene. The study involved 14 participants who received a single injection of the CRISPR/Cas9-based medicine, EDIT-101, which showed measurable improvements in 11 participants' vision.
          Read More
          This shows RNA.
          FeaturedGeneticsNeuroscience
          ·July 3, 2023·6 min read

          AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

          Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR tools. This new approach allows the fine-tuning of gene activity in human cells.
          Read More
          This shows cancer cells
          Brain CancerFeaturedGeneticsNeuroscience
          ·April 10, 2023·3 min read

          Identifying Cancer Genes’ Multiple Personalities

          A new method using the gene-editing tool CRISPR-Cas9 has been developed to model liver cancer tumor subtypes caused by mutations in the same genes. By targeting a single section of the mouse gene, Ctnnb1, researchers were able to produce two distinct tumor subtypes, enhancing protein activity to promote tumor growth, which could allow for the development of new therapeutic interventions in the future.
          Read More
          This shows retinal cells
          FeaturedGeneticsNeuroscienceVisual Neuroscience
          ·March 17, 2023·3 min read

          CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

          Using a highly versatile form of CRISPR gene editing, researchers successfully restored vision in mice with retinitis pigmentosa.
          Read More
          This shows the outline of a head
          FeaturedGeneticsNeurologyNeuroscience
          ·January 30, 2023·5 min read

          How Our Brains Turn Into Smarter Disease Fighters

          CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
          Read More
          This shows a brain
          FeaturedGeneticsNeurologyNeuroscience
          ·January 20, 2023·4 min read

          New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

          Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.
          Read More
          This shows a diagram from the study
          Brain CancerFeaturedNeurologyNeuroscience
          ·January 4, 2023·4 min read

          Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

          A new stem cell therapy approach eliminates established brain tumors and provides long-term immunity, training the immune system to prevent cancer from returning.
          Read More
          This shows neurons
          FeaturedGeneticsNeurologyNeuroscience
          ·December 12, 2022·4 min read

          CRISPR Technology Improves Huntington’s Disease Symptoms in Models

          Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.
          Read More
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          This shows an arrogant looking man.

          Most People Overestimate Their Moral Courage Under Pressure

          This shows a neuron.

          RyR1 Channel Triggers Sedation from Anesthetics

          This shows a brain.

          Teen Sleep Patterns May Shape Brain Disorder Risk

          This shows Legos.

          LEGO Lessons Boost Kids’ Math and Spatial Skills in 6 Weeks

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