Latest

gene editing

·July 3, 2023·6 min read

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR tools. This new approach allows the fine-tuning of gene activity in human cells.

Brain Cancer Featured Genetics Neuroscience

·April 10, 2023·3 min read

Identifying Cancer Genes’ Multiple Personalities

A new method using the gene-editing tool CRISPR-Cas9 has been developed to model liver cancer tumor subtypes caused by mutations in the same genes. By targeting a single section of the mouse gene, Ctnnb1, researchers were able to produce two distinct tumor subtypes, enhancing protein activity to promote tumor growth, which could allow for the development of new therapeutic interventions in the future.

Featured Genetics Neuroscience Visual Neuroscience

·March 17, 2023·3 min read

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

Using a highly versatile form of CRISPR gene editing, researchers successfully restored vision in mice with retinitis pigmentosa.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Genetics Neurology Neuroscience

·January 20, 2023·4 min read

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.

Brain Cancer Featured Neurology Neuroscience

·January 4, 2023·4 min read

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

A new stem cell therapy approach eliminates established brain tumors and provides long-term immunity, training the immune system to prevent cancer from returning.

Featured Genetics Neurology Neuroscience

·December 12, 2022·4 min read

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.

Featured Genetics Neurology Neuroscience

·September 22, 2022·5 min read

Pigs With Gene Defect Provide New Perspectives for the Treatment of Alzheimer’s

New research in cloned pigs with a mutation of the SORL1 sheds light on Alzheimer's development. The findings could pave the way for new treatments for the neurodegenerative disorder.

Featured Neurology Neuroscience

·August 14, 2022·5 min read

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

Using CRISPR gene editing, researchers were able to control microglia and reverse their toxic state associated with Alzheimer's disease, and put them back on track.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·May 7, 2022·4 min read

A ‘Factory Reset’ for the Brain Could Cure Anxiety and Drinking Behavior

Gene editing could be a potential new treatment for anxiety and alcohol use disorder in adults who indulged in binge drinking as adolescence.

Featured Neuroscience Open Neuroscience Articles

·April 29, 2022·3 min read

Clues Into a Sleep Mystery

Using gene editing to disrupt a gene in the thalamus that codes for a protein that binds to GABA boosted the activity of delta waves and promoted deep sleep in mouse models.

Featured Genetics Neuroscience

·January 23, 2022·8 min read

First Clinical-Grade Transplant of Gene-Edited Pig Kidneys Into Brain-Dead Human

Researchers successfully transplanted genetically modified, clinical-grade pig kidneys into a brain-dead human, replacing their native kidneys. The results demonstrate how xenotransplantation could help address organ shortages.

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gene editing

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

Identifying Cancer Genes’ Multiple Personalities

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

How Our Brains Turn Into Smarter Disease Fighters

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Pigs With Gene Defect Provide New Perspectives for the Treatment of Alzheimer’s

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

A ‘Factory Reset’ for the Brain Could Cure Anxiety and Drinking Behavior

Clues Into a Sleep Mystery

First Clinical-Grade Transplant of Gene-Edited Pig Kidneys Into Brain-Dead Human

Chronic Stress and Depression Linked to Alzheimer’s Risk

Playful Brains: Early Years Play Shapes Children’s Futures

Sleep Struggles Link to Elevated Risk of Hypertension

MDMA Makes People Feel More Connected During Conversations

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