Gene editing could be a potential new treatment for anxiety and alcohol use disorder in adults who indulged in binge drinking as adolescence.
Using gene editing to disrupt a gene in the thalamus that codes for a protein that binds to GABA boosted the activity of delta waves and promoted deep sleep in mouse models.
Researchers successfully transplanted genetically modified, clinical-grade pig kidneys into a brain-dead human, replacing their native kidneys. The results demonstrate how xenotransplantation could help address organ shortages.
Gene editing may provide hope for the treatment of Fragile X, the leading genetic cause of autism.
The dSlo2 channel appears to play a role in suppressing hyperactivity in the brain that causes epileptic seizures.
Mouse study identifies specific neurons and a signaling pathway to regions of the hindbrain that mediate sexual reproductive activity and physical activity that appear to influence activity behaviors during ovulation. The findings may provide valuable insights into how estrogen loss during menopause disrupts this activity.
People are less averse to the use of CRISPR gene editing in agriculture if the technology is used to promote disease resistance in animals. However, people tend to dislike the use of CRISPR when it comes to new breeding methods.
CRISPR gene-editing technology allowed researchers to pinpoint specific neurons and mechanisms related to the effects of oxidative stress in the brain.
PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.
Study reveals how a protein that transports essential amino acids across the placenta plays a role in fetal development. Deficiencies of the SNAT4 protein may result in developmental abnormalities and a higher risk of miscarriage.
Using CRISPR to alter the expression of four schizophrenia implicated genes which harbor expression quantitative trait loci, researchers were able to mirror gene expression changes seen in postmortem brains of those suffering from three mental health disorders.
Using CRISPR gene editing, researchers introduce the SHANK3 gene variant into macaque monkeys. SHANK3 has previously been linked to autism in humans. The monkeys with the SHANK3 mutations exhibited behavioral traits and brain activity patterns similar to those seen in humans on the autism spectrum, Researchers hope the new model will facilitate new avenues of research for ASD.
