GABA

This shows a male and female head surrounded by different colors

The neurobiological mechanisms behind schizophrenia may depend on gender

Schizophrenia is linked to alterations in pathways associated with glycosaminoglycan, neurotransmitter metabolism, and GABAergic synapses. A large percentage of genes related to schizophrenia are expressed differently between males and females. The results imply the mechanisms involved in schizophrenia development differ, at least slightly, between males and females.... Read More...
this is the organoid

Targeting key gene could help lead to down syndrome treatment

Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development. ... Read More...
This shows the lead research looking after a baby in a neonatal ward

Placental function linked to brain injuries associated with autism

Disruptions in the supply of allopregnanolone, a hormone created by the placenta late in pregnancy, to the developing fetus can leave children more vulnerable to brain injuries associated with ASD. Losing the supply of ALLO alters cerebellar development, an area of the brain critical for motor coordination and social cognition, impacting the post-birth development of cerebellar white matter. An experimental model revealed deficient cerebellar white matter resulted in social impairments and an increase in repetitive behaviors, two hallmark features associated with autism. ... Read More...