Cryo-electron microscopy captures detailed snapshots of the GABAB receptor protein contorts as it interacts with GABA. Read More
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Researchers identified a distinct population of GABAergic neurons activated by general anesthetic in the central amygdala of mice. The findings point to central amygdala GABAergic neurons as a potential therapeutic target to alleviate chronic pain. Read More
Neurons in the caudal pedunculopontine nucleus, an area of the brain that regulates motor coordination, switch neurotransmitters from acetylcholine to GABA as a result of exercise. The switch appears to provide feedback control that regulates motor coordination and skill learning. Read More
Study shows how Toxoplasma parasitic infections promote the loss of inhibitory signaling in the brain by altering the behavior of microglia. Read More
Each breath begins with hundreds of individual neurons haphazardly firing at low levels, then quickly synchronizing. The synchronization prompts activity that signals diaphragm and chest muscles to contract, causing expansion and inhalation. As the signal subsides, exhalation occurs. Read More
Mice lacking the autism-associated SHANK3 gene were more sensitive to sensation, including touch. The mice also had overactive excitatory neurons in the somatosensory cortex, which may account for sensory hypersensitivity. Read More
GABA can selectively regulate the excitability of neurons. Read More
A drug commonly prescribed for edema improves the symptoms for young children on the autism spectrum with no significant side effects. The drug, bumetanide, decreases the ratio of GABA to glutamate in the brain. Read More
Hangxiety, the feeling of waking up with anxiety the morning after heavy drinking, is a common symptom associated with a hangover. Researchers explain how a heavy night's drinking alters neurochemistry, leaving some of us prone to waking with anxiety. Read More
Different classes of neurons in the ventral pallidum control positive and negative motivations, sending opposing signals along a shared motivation-processing circuit. Read More
From reducing memory capability to increasing the risk of diabetes and obesity, researchers investigate how sugar affects the brain and body. Read More
Schizophrenia is linked to alterations in pathways associated with glycosaminoglycan, neurotransmitter metabolism, and GABAergic synapses. A large percentage of genes related to schizophrenia are expressed differently between males and females. The results imply the mechanisms involved in schizophrenia development differ, at least slightly, between males and females. Read More
