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FTD

·October 18, 2024·6 min read

How a Brain Lipid’s Production Could Impact Dementia

Researchers have discovered how a lipid molecule, BMP, crucial for brain function, is produced, potentially opening new doors for treating neurodegenerative diseases like Alzheimer’s and frontotemporal dementia. Two enzymes, PLD3 and PLD4, were found to catalyze the formation of BMP by changing the molecule’s “handedness,” allowing it to remain stable in lysosomes where other lipids are broken down.

Featured Genetics Neurology Neuroscience

·June 14, 2024·5 min read

FUS Protein Linked to FTD and ALS Spread

A new study reveals how the FUS protein aggregates and spreads in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The research shows that misfolded FUS proteins act like prions, spreading disease within the brain and exacerbating neurodegeneration. This discovery opens new avenues for therapeutic strategies targeting protein aggregate spread.

Featured Genetics Neurology Neuroscience

·March 22, 2024·7 min read

ALS and Dementia Share Molecular Links

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) share remarkably similar cellular and molecular characteristics despite their different clinical manifestations. The study analyzed RNA expression in over 620,000 cells from the motor and prefrontal cortex of 73 donors, revealing nearly identical changes in gene expression in the most vulnerable neurons across both diseases. This suggests potential therapeutic targets for ALS may also be effective for FTLD, and vice versa.

Featured Genetics Neurology Neuroscience

·December 6, 2023·5 min read

Key Protein in Frontotemporal Dementia Uncovered

The protein TAF15 is responsible for certain cases of frontotemporal dementia. Previously, the protein causing this type of dementia remained unidentified in about 10% of cases.

Featured Genetics Neurology Neuroscience

·May 9, 2023·4 min read

Shared Genetic Defects in ALS and FTD: New Insights Into Neurodegeneration

Some patients with ALS/motor neuron disease (MND) and frontotemporal dementia (FTD) carry the same rare genetic defects that cause other neurodegenerative diseases. These defects, known as short tandem repeat expansions, are the cause of more than 20 neurodegenerative diseases including spinocerebellar ataxias and myotonic dystrophy.

Featured Neurology Neuroscience

·April 24, 2023·4 min read

Antiviral Pathway a Potential New Target for Alzheimer’s Treatment

Inhibiting cGAS, an innate immune system enzyme allows neurons to become more resilient to tau fibrils. The new finding may serve in the development of new therapies to help treat Alzheimer's disease and frontotemporal dementia, two neurodegenerative disorders associated with tau build-up in the brain.

Featured Neurology Neuroscience

·January 24, 2023·4 min read

Potential Hidden Cause of Dementia Discovered

Some patients diagnosed with behavioral-variant frontotemporal dementia (bv-FTD) may instead be suffering from a cerebrospinal fluid leak that leads to brain sagging.

Featured Genetics Neurology Neuroscience

·December 21, 2022·6 min read

Study Traces Shared and Unique Cellular Hallmarks Found in 6 Neurodegenerative Diseases

Multiple neurodegenerative disorders harbor similar fundamental dysfunctional cellular processes.

Featured Neurology Neuroscience

·November 26, 2022·5 min read

Educational Background and Previous Brain Injury May Be Associated With Higher Risk of Frontotemporal Dementia

Previous TBI increased the risk of frontotemporal dementia in those without a genetic risk factor for FTD. Additionally, researchers found those with FTD tend to be less educated than those with Alzheimer's disease.

This shows the outline of a head covered with a magnifying glass and question mark

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·October 30, 2022·6 min read

New Clues Into a Serious Neurodegenerative Disease, Frontotemporal Dementia

A genetic form of frontotemporal dementia is associated with abnormal lipid accumulation in the brain fueled by disrupted cell metabolism. The findings could pave the way for new targeted therapies for FTD.

This shows the outline of a head and a brain

Featured Neurology Neuroscience

·October 16, 2022·4 min read

Speech as a New Diagnostic Tool in ALS and FTD

With the help of AI, researchers are developing digital biomarkers that use speech data to identify ALS and frontotemporal dementia.

Featured Neurology Neuroscience

·October 13, 2022·5 min read

Memory and Logic Test Detects Dementia Signs up to Nine Years Ahead of Diagnosis

People who later developed Alzheimer's disease scored poorly on memory and logic-based tests, as well as reaction times and grip tests. They were also more likely to have experienced a fall within the past 12 months. Those who developed PSP were twice as likely to experience a fall.

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FTD

How a Brain Lipid’s Production Could Impact Dementia

FUS Protein Linked to FTD and ALS Spread

ALS and Dementia Share Molecular Links

Key Protein in Frontotemporal Dementia Uncovered

Shared Genetic Defects in ALS and FTD: New Insights Into Neurodegeneration

Antiviral Pathway a Potential New Target for Alzheimer’s Treatment

Potential Hidden Cause of Dementia Discovered

Study Traces Shared and Unique Cellular Hallmarks Found in 6 Neurodegenerative Diseases

Educational Background and Previous Brain Injury May Be Associated With Higher Risk of Frontotemporal Dementia

New Clues Into a Serious Neurodegenerative Disease, Frontotemporal Dementia

Speech as a New Diagnostic Tool in ALS and FTD

Memory and Logic Test Detects Dementia Signs up to Nine Years Ahead of Diagnosis

Emotional Bonding: How Dog-Owner Heart Rates Sync During Interaction

Pathway Identified for Early Intervention in ALS Progression

Chimpanzees’ Task Performance Changes When Observed by Humans

Insights on Brain Aging and Lifelong Cognitive Health

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