Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.
Study confirms neurofilament light is a useful blood-based biomarker for frontotemporal dementia, PSP, and primary progressive aphasia.
Patients who suffer from frontotemporal dementia with extrapyramidal symptoms have brainstem atrophy and reduced metabolic activity in specific brain regions compared to those with FTD without extrapyramidal symptoms.
PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.
Damage to the multiple demand network, a brain network associated with general intelligence, causes people with dementia to struggle to adapt to changes in their environment
Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.
Researchers recreated the damage seen in frontotemporal dementia in brain organoid models. The study reveals an experimental drug designed to treat Crohn's disease may help prevent neuron death associated with FTD.
Researchers report Alzheimer's disease and other neurodegenerative disorders can be confirmed in living patients by specific biomarkers in cerebrospinal fluid.
Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.
NfL, a single biomarker in the blood, can accurately predict the presence of underlying neurodegenerative disorders, such as FTD and ALS, in people with cognitive problems.
Study links anhedonia, or the loss of pleasure, to the early onset of frontotemporal dementia. Neuroimaging revealed symptoms of anhedonia were marked by atrophy in the frontal and striatal brain areas of those with FTD.
The LSM12-EPAC1 pathway is an important suppressor of the NCT-related pathologies associated with ALS and FTD.
