Some patients diagnosed with behavioral-variant frontotemporal dementia (bv-FTD) may instead be suffering from a cerebrospinal fluid leak that leads to brain sagging.
Multiple neurodegenerative disorders harbor similar fundamental dysfunctional cellular processes.
Previous TBI increased the risk of frontotemporal dementia in those without a genetic risk factor for FTD. Additionally, researchers found those with FTD tend to be less educated than those with Alzheimer's disease.
A genetic form of frontotemporal dementia is associated with abnormal lipid accumulation in the brain fueled by disrupted cell metabolism. The findings could pave the way for new targeted therapies for FTD.
With the help of AI, researchers are developing digital biomarkers that use speech data to identify ALS and frontotemporal dementia.
People who later developed Alzheimer's disease scored poorly on memory and logic-based tests, as well as reaction times and grip tests. They were also more likely to have experienced a fall within the past 12 months. Those who developed PSP were twice as likely to experience a fall.
Study reveals striking similarities in both behaviors and neuroanatomical changes between people with schizophrenia and behavioral-variant frontotemporal dementia.
Amyloid fibrils in those with frontotemporal lobar degeneration (FTLD) contain a little-known protein called TMEM106B. Researchers speculate TMEM106B could be found to be the cause of FTLD.
Study confirms neurofilament light is a useful blood-based biomarker for frontotemporal dementia, PSP, and primary progressive aphasia.
Patients who suffer from frontotemporal dementia with extrapyramidal symptoms have brainstem atrophy and reduced metabolic activity in specific brain regions compared to those with FTD without extrapyramidal symptoms.
PolyP, an inorganic polyphosphate released by astrocytes in people with ALS and frontotemporal dementia contributes to the signature motor neuron death associated with the disease pathologies.
Damage to the multiple demand network, a brain network associated with general intelligence, causes people with dementia to struggle to adapt to changes in their environment
