Fragile X syndrome patients with prematuration had a much earlier onset of neurological problems, including earlier symptoms of neurodegeneration. They also experienced emotional processing problems. Some of the most common emotional processing disorders reported were mood regulation, anxiety, and psychosis.
Study identifies a short gene segment crucial for brain development and information processing. The absence of the gene segment induces altered social behaviors, learning difficulties, and memory deficits, which are hallmarks of a subset of ASD.
Stem cell study reveals a genetic defect associated with fragile X syndrome delays the production of neurons during a critical stage of embryonic development.
Researchers have derived purkinje cells from patients with TSC, a genetic syndrome that includes some ASD-like symptoms. The cells, researchers say, have several characteristics that could help explain how ASD develops at the molecular level.
A pre-clinical mouse study may provide an exciting new step toward developing new treatment approaches for Fragile X.