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FKBP5

·March 1, 2023·3 min read

Stress Gene Dysregulation Found in Kids After Injury From Abuse vs. Accident

Study reports on epigenetic changes to the FKBP5 gene, a key gene associated with the regulation of stress response in the body, in babies and young children who were injured as a result of abuse, but not accidental injury.

Featured Neuroscience Psychology

·November 18, 2022·5 min read

Can Pharmacotherapies Prevent Alcohol Use Disorder in People With PTSD?

Those with PTSD are almost twice as likely to develop alcohol use disorder than their peers who have not experienced trauma. Researchers report drugs that block FKBP5, such as benztropine, a drug used to control symptoms of Parkinson's disease, and the experimental compound SAFit2 reduce alcohol preference and drinking in models of PTSD.

Featured Neuroscience Psychology

·June 19, 2021·2 min read

Details Behind the Body’s Response to Stress Revealed

Study reveals how key proteins regulate the brain's response to stress in the hippocampus.

Featured Genetics Neuroscience Psychology

·June 11, 2019·4 min read

Early life stress plus overexpressed FKBP5 protein increases anxiety behavior

Early life adversity, coupled with overexpression of the FKBP5 protein, increase susceptibility for later neuropsychiatric disorders, a new mouse study reveals. The association is more pronounced in females.

Featured Genetics Psychology

·February 13, 2017·3 min read

Gene That Helps Form Trauma Related Memories May Also Help Prevent PTSD

Researchers report a steroid routinely given to reduce inflammation can alter the expression of a gene associated with fear extinction, preventing the formation of fear memories associated with PTSD.

The image shows neural stem cells derived from people with bipolar disorder.

Featured Genetics

·April 11, 2013·4 min read

Do Drugs for Bipolar Disorder “Normalize” Brain Gene Function?

A new brain tissue study has shown gene expression in bipolar patients treated with antipsychotic medications is similar to the expression in subjects with no history of bipolar disorder.