The release of 2-AG, a natural endocannabinoid that is suggested to be the brain's equivalent to THC, dampens down seizure activity but increases post-seizure oxygen deprivation in the brain.
GABA accelerates the breakdown of endocannabinoids in the brain. Endocannabinoids are critical for emotional processing. The findings could lead to the development of new treatments for emotional behavioral disorders.
An imbalance in gut bacteria can cause the reduction of some metabolites, resulting in depression-like symptoms. The findings contribute to the growing body of evidence for the role the microbiome plays in brain function and mental health.
Anandamide, an endogenous compound produced in the body, plays a role in reversing memories of traumatic events. The findings could lead to new treatments for PTSD.
A variant of the FAAH gene increases vulnerability to THC in females and has a larger-scale impact on brain regions responsible for reward processing.
When pregnant women consume diets high in polyunsaturated omega-6 fatty acids, an excess of endocannabinoids is produced which overloads the fetus, and impairs healthy brain development.
Fatty acid amide hydrolase (FAAH) inhibitors, a form of medication that boosts endocannabinoids, may be helpful in the treatment of PTSD. FAAH inhibition can improve the recall of fear extinction memories. The drugs could also help treat stress and other psychological disorders.
Moderate intensity exercise significantly boosts endocannabinoids and improves mood for those with major depressive disorder.
While endocannabinoids have been reported to play a role in anti-inflammation in some areas of the brain, a new study reveals they may cause inflammation in the cerebellum.
The secretory pathway delivery of cannabinoid type 1 receptor is axonally based, and surface expressed CB1R is more stable in axons than dendrites.
Cannabis consumption during pregnancy is associated with a slightly increased risk of a child developing psychosis at age ten. The findings also shed new light on the role endocannabinoids play in neurodevelopment.
A rare genetic mutation has been associated with pain insensitivity. The findings could further research into new treatments to target pain.
