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dorsal vagal complex

·May 26, 2025·4 min read

Brainstem Neurons Hold Key to Semaglutide’s Weight Loss Effects

Researchers have identified a specific group of brainstem neurons that mediate the appetite-reducing and weight-loss effects of semaglutide without triggering side effects like nausea. In mice, activating these neurons led to reduced food intake and fat loss, mimicking the drug’s benefits.

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Featured Neuroscience

·November 1, 2022·5 min read

The Neural Pathways for Vomiting After Eating Infected Food

After eating contaminated food, toxins activate the release of serotonin by the enterochromaffin cells on the lining of the intestinal lumen. The serotonin binds to receptors on vagal sensory neurons in the gut, transmitting signals along the vagus nerve to neurons in the dorsal vagal complex, inducing retching behaviors.