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dementia

·January 1, 2020·5 min read

Objective subtle cognitive difficulties predict amyloid accumulation and neurodegeneration

Amyloid accumulation occurs faster in those who have objectively-defined cognitive difficulties than older people who are considered to be cognitively normal. Mild cognitive impairment is also associated with faster hippocampal and entorhinal cortex atrophy.

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·December 31, 2019·4 min read

Possible dementia vaccine closer after mice studies

Clinical trials for a preventative treatment for dementia was successful in mouse models. Researchers say human trials will begin in two years.

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·December 29, 2019·7 min read

Drugs that quell brain inflammation reverse dementia

Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age.

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·December 26, 2019·3 min read

High fat diet impairs new neuron creation in female mice

Female mice exposed to a high-fat diet have limited hippocampal neurogenesis. The findings may explain why women are at higher risk of developing dementia than men.

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·December 19, 2019·4 min read

Is there a link between lifetime lead exposure and dementia?

A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead.

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·December 18, 2019·4 min read

Is herpes virus infections linked to Alzheimer’s disease?

Study finds no link between the abundance of herpes viral DNA or RNA and an increased risk of developing Alzheimer's disease.

This is a drawing of a hand holding a head with an exposed brain

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·December 13, 2019·3 min read

How a protein in your brain could protect against Alzheimer’s disease

White blood cells in the brain are regulated by the CD33 protein. CD33 decreases the likelihood that a person will develop Alzheimer's disease.

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·December 11, 2019·4 min read

Your genes aren’t the only factor dictating Alzheimer’s risk

While genetics may increase your risk of developing dementia, other factors such as lifestyle and environment may play a key role in the development and progression of Alzheimer's disease.

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·December 10, 2019·4 min read

Alzheimer’s drug candidates reverse broader aging

CMS121 and J147, two drug candidates that improve memory and slow neurodegeneration associated with Alzheimer's disease, also slow aging in healthy, older mice. The compounds block damage to neurons caused by general aging and restore levels of specific molecules to those seen in younger animals.

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·December 4, 2019·6 min read

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.

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·November 29, 2019·3 min read

Tai Chi brings benefits for people with dementia

Tai Chi improved quality of life and reduced falls in older people with dementia.

This shows an older couple riding bicycles

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·November 29, 2019·5 min read

Aerobic exercise and heart-healthy diet may slow development of memory problems

Combining aerobic exercise with the heart-healthy DASH diet improved the ability to think, recall, and make decisions in older people who experienced cognitive decline and mild cognitive impairment.