Corticotropin-releasing factor and neuropeptide Y work in synchronized opposition to each other to remodel and rewire neurons in the amygdala as a response to stress. The process, researchers say, can be manually reversed to help relieve anxiety.
Chronic stress can affect a person's health and mental well being. Due to the COVID-19 virus, chronic stress is on the rise worldwide. Researchers examine the general and psychological health implications of chronic stress and suggest some methods we can adopt to keep our stress levels in check.
Researchers uncover a key role of medial prefrontal cortex corticotropin-releasing factor interneurons for bidirectionally controlling motivated behavioral styles under stress. The findings could help in the development of new treatments for PTSD.
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.
Optogenetic inactivation of CRF neurons in the central nucleus of the amygdala decreases escalation of alcohol consumption and intensity of withdrawal in rodent models of alcoholism. The findings suggest a potential target for treating excessive drinking in alcohol use disorder.
A new study reveals a unique population of corticotropin releasing factor neurons in female mice that may mediate differences in stress response.
According to a new study, men have a stronger positive correlation between cardiorespiratory fitness and brain function as they age.
According to a new study, alcohol increases neural activity in the central amygdala.
Older adults with high cardiorespiratory fitness scored performed better on memory tests than those with lower scores, a new study reports.
Researchers explore how stress can influence our cognitive performance.
Researchers have identified a neural circuit between two brain areas that appears to control binge drinking.
Using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's neuropathology and prevents the onsite of cognitive impairment in mouse models of the disease, a new study reports.
