A newly developed brain model from cultivated stem cells allowed researchers to analyze molecular pathways of neurons in a dish. Researchers identified specific forms of amyloid beta and tau associated with cognitive decline and Alzheimer's. They also uncovered signaling pathways that influence the production of the toxic proteins.
A new test reveals an association between poor lifestyle choices and an increased risk of cognitive decline leading to dementia.
New studies have identified an association between daily high coffee consumption, brain shrinkage and an increased risk of dementia. However, researchers were unable to identify a causal relationship between caffeine consumption and dementia. The study also found moderate coffee consumption was associated with lower dementia risk than high consumption, or abstaining from caffeinated drinks.
Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.
Diet and exercise can influence hippocampal neurogenesis, researchers say. Poor nutrition and lack of exercise have detrimental effects on hippocampal neurogenesis, increasing the risk for dementia.
Study reaffirms findings that the gut microbiome may play a significant role in cognitive decline. Researchers found, in mice, a ketogenic diet, hypoxia, and the Bilophila wadsworthia bacteria impaired the hippocampus, leading to signs of cognitive decline.
Dipeptidyl peptidase-4 inhibitors, a class of drug that reduces blood sugar in type 2 diabetes, were associated with less amyloid accumulation in the brain and slower cognitive decline in patients.
The gut microbiome can be harnessed to reverse age-related brain deterioration and restore cognitive function, researchers report.
60% of 400 coronavirus survivors experienced lasting cognitive impairment, a new study reports. Cognitive problems were found in those who experienced mild-to-moderate COVID symptoms, as well as those who experienced more severe symptoms. One in three of the survivors experienced severe cognitive symptoms, akin to dementia.
A diet that consists of at least half a serving of flavonoid-rich foods per day reduces the risk of cognitive decline in older adults by 20%.
Reduction of semantic memory could be an indicator of Alzheimer's disease 12 years before onset. Researchers examine different types of memory loss associated with dementia.