People with genetic risks for Alzheimer's disease may exhibit changes in brain structure and reduced performance in cognitive tests long before symptoms of the neurodegenerative disease become obvious.
PET study finds early accumulation of the tau protein in the brain is a better predictor of Alzheimer's associated memory decline than amyloid plaque accumulation or cerebrospinal fluid biomarkers.
Higher glucose levels detected by a two-hour glucose test were an accurate predictor of poorer performance in tests of episodic memory ten years later.
Researchers have identified four cognitive profiles associated with menopause. Findings reveal women who experience stronger verbal learning and memory, in addition to better attention and executive function during menopause, are less likely to experience hot flashes and depression. Women who experienced cognitive weakness had an increased risk of depression and sleep disruptions.
A newly developed brain model from cultivated stem cells allowed researchers to analyze molecular pathways of neurons in a dish. Researchers identified specific forms of amyloid beta and tau associated with cognitive decline and Alzheimer's. They also uncovered signaling pathways that influence the production of the toxic proteins.
A new test reveals an association between poor lifestyle choices and an increased risk of cognitive decline leading to dementia.
New studies have identified an association between daily high coffee consumption, brain shrinkage and an increased risk of dementia. However, researchers were unable to identify a causal relationship between caffeine consumption and dementia. The study also found moderate coffee consumption was associated with lower dementia risk than high consumption, or abstaining from caffeinated drinks.
Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.
Diet and exercise can influence hippocampal neurogenesis, researchers say. Poor nutrition and lack of exercise have detrimental effects on hippocampal neurogenesis, increasing the risk for dementia.
Study reaffirms findings that the gut microbiome may play a significant role in cognitive decline. Researchers found, in mice, a ketogenic diet, hypoxia, and the Bilophila wadsworthia bacteria impaired the hippocampus, leading to signs of cognitive decline.
Dipeptidyl peptidase-4 inhibitors, a class of drug that reduces blood sugar in type 2 diabetes, were associated with less amyloid accumulation in the brain and slower cognitive decline in patients.