Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
NKAP-related syndrome, a newly identified neurodevelopmental disorder caused by mutations in the NKPA gene, causes developmental delays, intellectual disabilities, behavioral abnormalities, and musculoskeletal problems in children.
Nonverbal children on the autism spectrum have a slower response to auditory stimulation. The longer response times were associated with poor communication skills. Brain imaging of the auditory cortex could serve as a biomarker for measuring the likelihood of language impairment in those with ASD.
S1PR3, a receptor found on the surface of brain cells, may play a key role in stress resilience. Veterans with severe PTSD symptoms had lower levels of the S1PR3 protein in their blood than peers without the disorder.
The gut microbiome contributes to depression-like behaviors and inflammation in the ventral hippocampus, according to a new rat study. Fecal transplants from rats with lower levels of Clostridia reduced depressive behaviors and inflammation in vulnerable rodents.