Three different autism risk genes affect similar aspects of neural formation and the same types of neurons in the developing human brain.
Using human stem cells to develop a brain organoid model, researchers were able to show exposure to a common pesticide synergizes with an autism-linked gene mutation. The study provides clear evidence that genetics and environment may combine to disrupt neurodevelopment.
CHD8, a gene associated with autism plays a significant role in oligodendrocyte development, researchers report.
Researchers report that inducing mutation of the CHD8 gene, mice experience cognitive impairments and have increased brain volume. Both conditions are also seen in people with CHD8 mutations. The findings suggest CHD8 plays a role in brain function throughout life and could affect more that early brain development in people on the autism spectrum.
According to researchers, maternal immune activation during pregnancy can disrupt the expression of genes and processes associated with Autism.
A new study identifies common genomic defects that may explain why children with autism have an abnormal number of brain cells and abnormal brain growth.
