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CGRP

·July 13, 2024·5 min read

Brain’s Lymphatic System Plays Role in Migraine Pain

Researchers discovered how the protein CGRP affects the brain's lymphatic system, contributing to migraine pain. Their study reveals that CGRP prevents cerebrospinal fluid from draining, influencing migraine attacks. This finding could lead to new therapeutic strategies for migraines. More research is needed to understand the sex differences in migraine prevalence.

Featured Neuroscience

·October 14, 2022·7 min read

Unexpected Protective Properties of Pain

Pain neurons engage in direct cross-talk with goblet cells, or mucus-containing cells within the gut. During states of inflammation, pain cells stimulate goblet cells to release more mucus. Findings suggest the nervous system plays a key role in gut barrier maintenance and triggers protective mechanisms during periods of inflammation.

Featured Neuroscience Open Neuroscience Articles

·August 16, 2022·4 min read

How the Brain Gathers Threat Cues and Turns Them Into Fear

CGRP neurons found in subregions of the thalamus and brainstem relay multisensory threat information to the amygdala. These neural circuits are essential for the formation of aversive memories, a new study reports.

Featured Genetics Neurology Pain

·April 8, 2019·5 min read

Migraine-linked protein exhibits sex-specific pain effects

CGRP, a protein associated with migraine pain, appears to act differently between sexes. Researchers say a female-specific mechanism of downstream CGRP receptor activation is likely to contribute to the higher prevalence of migraine in women.

Featured Genetics Neurology

·November 30, 2017·5 min read

Phase III Immunotherapy Trial For Migraine Shows Promising Results

An immunotherapy that acts against an inflammatory molecule associated with migraines, has been shown to be successful in reducing the number of headaches people with chronic migraines suffer each month.